DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PDYTPELE
Uniprot ID:
P12525
Source protein:
Putative myc-like protein MYCLP1
Source gene:
MYCLP1
Class:
DEG_SCF_FBW7_2
Location:
124:131
E3 ligase:
FBXW7
DEGRON score:
0.9975
ASA_SCORE:
75.1625
COIL:
0.81
CONS_SCORE:
0.3159
DSS_SCORE:
0.4523
HELIX:
0.1211
FCONS_SCORE:
1.5484
RIG_SCORE:
0.7729
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MYCLP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PDYTPELE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P12525
Putative myc-like protein MYCLP1
DEG_SCF_FBW7_2
124:131
PDYTPELE
FBXW7
0.9975
More...