DegronMD

Uniprot ID: Q13487

Source protein: snRNA-activating protein complex subunit 2

Source gene: SNAPC2

Class: DEG_SCF_FBW7_1

Location: 289:296

E3 ligase: FBXW7

DEGRON score: 0.8334

ASA_SCORE: 95.825

COIL: 0.9156

CONS_SCORE: 0.5086

DSS_SCORE: 0.784

HELIX: 0.0661

FCONS_SCORE: 1.0249

RIG_SCORE: 0.6046

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H301Y	SIDM00373	Endometrial Carcinoma	GDSC	PEETPPAT	DEG_SCF_FBW7_1	0.1944
p.S302N	TCGA-DS-A0VL	CESC	TCGA	PEETPPAT	DEG_SCF_FBW7_1	0.1667
p.G283R	SIDM00139	Mesothelioma	GDSC	PEETPPAT	DEG_SCF_FBW7_1	0.1667
p.G283R	ACH-000367	Lung Cancer	CCLE	PEETPPAT	DEG_SCF_FBW7_1	0.1667
p.G283R	NCI-H226	lung	COSMIC	PEETPPAT	DEG_SCF_FBW7_1	0.1667
p.E303K	SIDM01611	Endometrial Carcinoma	GDSC	PEETPPAT	DEG_SCF_FBW7_1	0.1389
p.E303K	ACH-000996	Endometrial/Uterine Cancer	CCLE	PEETPPAT	DEG_SCF_FBW7_1	0.1389
p.S306L	TCGA-AP-A0LM	UCEC	TCGA	PEETPPAT	DEG_SCF_FBW7_1	0.0556
p.S306L	TCGA-D3-A51G	SKCM	TCGA	PEETPPAT	DEG_SCF_FBW7_1	0.0556
p.S306L	TCGA-ND-A4WC	UCS	TCGA	PEETPPAT	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13487	snRNA-activating protein complex subunit 2	DEG_SCF_FBW7_1	289:296	PEETPPAT	FBXW7	0.8334	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons