DegronMD

Uniprot ID: Q9NPY3

Source protein: Complement component C1q receptor

Source gene: CD93

Class: DEG_SCF_FBW7_1

Location: 506:513

E3 ligase: FBXW7

DEGRON score: 0.811

ASA_SCORE: 74.2125

COIL: 0.8169

CONS_SCORE: 0.364

DSS_SCORE: 0.8287

HELIX: 0.045

FCONS_SCORE: 0.9752

RIG_SCORE: 0.5478

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P510H	TCGA-05-4424	LUAD	TCGA	PEGTPKAT	DEG_SCF_FBW7_1	0.7694
p.P510H	DO23672	LUAD	ICGC	PEGTPKAT	DEG_SCF_FBW7_1	0.7694
p.R496S	TCGA-05-5420	LUAD	TCGA	PEGTPKAT	DEG_SCF_FBW7_1	0.0556
p.R496S	DO26005	LUAD	ICGC	PEGTPKAT	DEG_SCF_FBW7_1	0.0556
p.A500D	TCGA-56-A49D	LUSC	TCGA	PEGTPKAT	DEG_SCF_FBW7_1	0.1667
p.A500D	DO45475	LUSC	ICGC	PEGTPKAT	DEG_SCF_FBW7_1	0.1667
p.P502S	TCGA-90-A4ED	LUSC	TCGA	PEGTPKAT	DEG_SCF_FBW7_1	0.2222
p.P502S	DO45482	LUSC	ICGC	PEGTPKAT	DEG_SCF_FBW7_1	0.2222
p.S520L	TCGA-B5-A11E	UCEC	TCGA	PEGTPKAT	DEG_SCF_FBW7_1	0.1389
p.S520L	DO41644	UCEC	ICGC	PEGTPKAT	DEG_SCF_FBW7_1	0.1389
p.S520L	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PEGTPKAT	DEG_SCF_FBW7_1	0.1389
p.P510L	TCGA-BB-7870	HNSC	TCGA	PEGTPKAT	DEG_SCF_FBW7_1	0.7582
p.P510L	DO14378	HNSC	ICGC	PEGTPKAT	DEG_SCF_FBW7_1	0.7582
p.S523C	TCGA-E5-A4TZ	BLCA	TCGA	PEGTPKAT	DEG_SCF_FBW7_1	0.0556
p.S523C	DO44055	BLCA	ICGC	PEGTPKAT	DEG_SCF_FBW7_1	0.0556
p.G508S	TCGA-EE-A2GR	SKCM	TCGA	PEGTPKAT	DEG_SCF_FBW7_1	0.5882
p.G508S	DO37996	SKCM	ICGC	PEGTPKAT	DEG_SCF_FBW7_1	0.5882
p.R496C	TCGA-EO-A22X	UCEC	TCGA	PEGTPKAT	DEG_SCF_FBW7_1	0.0556
p.R496C	DO43907	UCEC	ICGC	PEGTPKAT	DEG_SCF_FBW7_1	0.0556
p.R496C	ACH-000975	Lung Cancer	CCLE	PEGTPKAT	DEG_SCF_FBW7_1	0.0556
p.R496H	TCGA-QG-A5Z2	COAD	TCGA	PEGTPKAT	DEG_SCF_FBW7_1	0.0556
p.R496H	DO44096	COAD	ICGC	PEGTPKAT	DEG_SCF_FBW7_1	0.0556
p.R496H	DO46877	RECA	ICGC	PEGTPKAT	DEG_SCF_FBW7_1	0.0556
p.R496H	SIDM00330	Neuroblastoma	GDSC	PEGTPKAT	DEG_SCF_FBW7_1	0.0556
p.R496H	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	PEGTPKAT	DEG_SCF_FBW7_1	0.0556
p.R496H	SIDM01144	Gastric Carcinoma	GDSC	PEGTPKAT	DEG_SCF_FBW7_1	0.0556
p.R496H	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	PEGTPKAT	DEG_SCF_FBW7_1	0.0556
p.R496H	SIDM00026	Other Solid Cancers	GDSC	PEGTPKAT	DEG_SCF_FBW7_1	0.0556
p.R496H	SIDM00273	Glioblastoma	GDSC	PEGTPKAT	DEG_SCF_FBW7_1	0.0556
p.R496H	SIDM01587	Bladder Carcinoma	GDSC	PEGTPKAT	DEG_SCF_FBW7_1	0.0556
p.R496H	SIDM00159	Biliary Tract Carcinoma	GDSC	PEGTPKAT	DEG_SCF_FBW7_1	0.0556
p.R496H	EC-GI-10	oesophagus	COSMIC	PEGTPKAT	DEG_SCF_FBW7_1	0.0556
p.R496H	LAN-6	autonomic_ganglia	COSMIC	PEGTPKAT	DEG_SCF_FBW7_1	0.0556
p.R496H	NCI-SNU-5	stomach	COSMIC	PEGTPKAT	DEG_SCF_FBW7_1	0.0556
p.R496H	LU-99A	lung	COSMIC	PEGTPKAT	DEG_SCF_FBW7_1	0.0556
p.R496H	TASK1	bone	COSMIC	PEGTPKAT	DEG_SCF_FBW7_1	0.0556
p.R496H	GI-1	central_nervous_system	COSMIC	PEGTPKAT	DEG_SCF_FBW7_1	0.0556
p.T515A	DO228947	LICA	ICGC	PEGTPKAT	DEG_SCF_FBW7_1	0.2778
p.T515N	DO229026	LICA	ICGC	PEGTPKAT	DEG_SCF_FBW7_1	0.2778
p.T499K	DO229031	LICA	ICGC	PEGTPKAT	DEG_SCF_FBW7_1	0.1389
p.A497S	DO50738	LICA	ICGC	PEGTPKAT	DEG_SCF_FBW7_1	0.0833
p.R504S	DO52155	PAEN	ICGC	PEGTPKAT	DEG_SCF_FBW7_1	0.2778
p.T499P	DO219872	SKCA	ICGC	PEGTPKAT	DEG_SCF_FBW7_1	0.1389
p.T499P	DO218908	SKCA	ICGC	PEGTPKAT	DEG_SCF_FBW7_1	0.1389
p.R504G	SIDM00081	Melanoma	GDSC	PEGTPKAT	DEG_SCF_FBW7_1	0.2778
p.R504G	SK-MEL-28	skin	COSMIC	PEGTPKAT	DEG_SCF_FBW7_1	0.2778
p.S517G	SIDM00907	Burkitt's Lymphoma	GDSC	PEGTPKAT	DEG_SCF_FBW7_1	0.2222
p.S517G	ACH-000440	Lymphoma	CCLE	PEGTPKAT	DEG_SCF_FBW7_1	0.2222
p.S517G	CA46	haematopoietic_and_lymphoid_tissue	COSMIC	PEGTPKAT	DEG_SCF_FBW7_1	0.2222
p.P519S	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PEGTPKAT	DEG_SCF_FBW7_1	0.1667
p.P519S	ACH-000916	Lung Cancer	CCLE	PEGTPKAT	DEG_SCF_FBW7_1	0.1667
p.P519S	NCI-H1573	lung	COSMIC	PEGTPKAT	DEG_SCF_FBW7_1	0.1667
p.A512S	ACH-001513	Cervical Cancer	CCLE	PEGTPKAT	DEG_SCF_FBW7_1	0.6477

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PEGTPKAT

Degron related mutations and impact score

Drug responses associated with CD93 mutations

All proteins holding degron of PEGTPKAT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NPY3	Complement component C1q receptor	DEG_SCF_FBW7_1	506:513	PEGTPKAT	FBXW7	0.811	More...