DegronMD

Uniprot ID: P36021

Source protein: Monocarboxylate transporter 8

Source gene: SLC16A2

Class: DEG_SCF_FBW7_2

Location: 77:84

E3 ligase: FBXW7

DEGRON score: 0.7132

ASA_SCORE: 103.825

COIL: 0.9195

CONS_SCORE: 0.302

DSS_SCORE: 0.7221

HELIX: 0.0283

FCONS_SCORE: 0.9324

RIG_SCORE: 0.6559

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E78K	TCGA-AX-A0J0	UCEC	TCGA	PEPTPTVE	DEG_SCF_FBW7_2	0.591
p.P94H	TCGA-AX-A2HD	UCEC	TCGA	PEPTPTVE	DEG_SCF_FBW7_2	0.0556
p.G91D	TCGA-CG-4305	STAD	TCGA	PEPTPTVE	DEG_SCF_FBW7_2	0.1389
p.R73W	TCGA-EO-A22R	UCEC	TCGA	PEPTPTVE	DEG_SCF_FBW7_2	0.2222
p.Q78L	DO22860	LIHC	ICGC	PEPTPTVE	DEG_SCF_FBW7_2	0.7765
p.P72S	DO37823	SKCM	ICGC	PEPTPTVE	DEG_SCF_FBW7_2	0.1944
p.A74V	DO42608	UCEC	ICGC	PEPTPTVE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P36021	Monocarboxylate transporter 8	DEG_SCF_FBW7_2	77:84	PEPTPTVE	FBXW7	0.7132	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons