DegronMD

Uniprot ID: P33316

Source protein: Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

Source gene: DUT

Class: DEG_SCF_FBW7_1

Location: 93:99

E3 ligase: FBXW7

DEGRON score: 0.895

ASA_SCORE: 86.4857

COIL: 0.9477

CONS_SCORE: 0.3928

DSS_SCORE: 0.7271

HELIX: 0.0146

FCONS_SCORE: 0.9556

RIG_SCORE: 0.6108

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P96S	TCGA-DU-6407	LGG	TCGA	PETPAIS	DEG_SCF_FBW7_1	0.6752
p.P96H	TCGA-FS-A1ZJ	SKCM	TCGA	PETPAIS	DEG_SCF_FBW7_1	0.7694
p.E106A	DO223732	CESC	ICGC	PETPAIS	DEG_SCF_FBW7_1	0.1389
p.L91F	DO228976	LICA	ICGC	PETPAIS	DEG_SCF_FBW7_1	0.2778
p.V103F	DO229026	LICA	ICGC	PETPAIS	DEG_SCF_FBW7_1	0.2222
p.V103F	DO229041	LICA	ICGC	PETPAIS	DEG_SCF_FBW7_1	0.2222
p.G90D	DO46657	PAAD	ICGC	PETPAIS	DEG_SCF_FBW7_1	0.25
p.A101T	DO51781	STAD	ICGC	PETPAIS	DEG_SCF_FBW7_1	0.2778
p.V100A	DO42472	UCEC	ICGC	PETPAIS	DEG_SCF_FBW7_1	0.3056
p.G92R	SIDM02058	Esophageal Carcinoma	GDSC	PETPAIS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P33316	Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial	DEG_SCF_FBW7_1	93:99	PETPAIS	FBXW7	0.895	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons