DegronMD

Uniprot ID: P11464

Source protein: Pregnancy-specific beta-1-glycoprotein 1

Source gene: PSG1

Class: DEG_SCF_FBW7_1

Location: 171:177

E3 ligase: FBXW7

DEGRON score: 0.8883

ASA_SCORE: 61.4714

COIL: 0.7163

CONS_SCORE: 0.3608

DSS_SCORE: 0.2639

HELIX: 0.0169

FCONS_SCORE: 1

RIG_SCORE: 0.7582

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A176T	TCGA-06-0142	GBM	TCGA	PETPDAS	DEG_SCF_FBW7_1	0.6028
p.A176T	DO44410	GBM	ICGC	PETPDAS	DEG_SCF_FBW7_1	0.6028
p.A176T	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	PETPDAS	DEG_SCF_FBW7_1	0.6028
p.A176T	ACH-000158	Lymphoma	CCLE	PETPDAS	DEG_SCF_FBW7_1	0.6028
p.Q185L	TCGA-17-Z001	LUAD	TCGA	PETPDAS	DEG_SCF_FBW7_1	0.1111
p.Y178N	TCGA-24-1434	OV	TCGA	PETPDAS	DEG_SCF_FBW7_1	0.3056
p.Y178N	DO28014	OV	ICGC	PETPDAS	DEG_SCF_FBW7_1	0.3056
p.T168N	TCGA-39-5040	LUSC	TCGA	PETPDAS	DEG_SCF_FBW7_1	0.25
p.T168N	DO45436	LUSC	ICGC	PETPDAS	DEG_SCF_FBW7_1	0.25
p.G184S	TCGA-90-A4ED	LUSC	TCGA	PETPDAS	DEG_SCF_FBW7_1	0.1389
p.G184S	DO45482	LUSC	ICGC	PETPDAS	DEG_SCF_FBW7_1	0.1389
p.Y178C	TCGA-AZ-4315	COAD	TCGA	PETPDAS	DEG_SCF_FBW7_1	0.3056
p.Y178C	DO8842	COAD	ICGC	PETPDAS	DEG_SCF_FBW7_1	0.3056
p.Y178C	SNU-1040	large_intestine	COSMIC	PETPDAS	DEG_SCF_FBW7_1	0.3056
p.S186N	TCGA-BR-7707	STAD	TCGA	PETPDAS	DEG_SCF_FBW7_1	0.0833
p.S186N	DO38487	STAD	ICGC	PETPDAS	DEG_SCF_FBW7_1	0.0833
p.L187H	TCGA-DM-A28K	COAD	TCGA	PETPDAS	DEG_SCF_FBW7_1	0.0556
p.L187H	DO8167	COAD	ICGC	PETPDAS	DEG_SCF_FBW7_1	0.0556
p.M182T	TCGA-L5-A4OO	ESCA	TCGA	PETPDAS	DEG_SCF_FBW7_1	0.1944
p.M182I	DO222652	BTCA	ICGC	PETPDAS	DEG_SCF_FBW7_1	0.1944
p.E172Q	DO222761	ESCA	ICGC	PETPDAS	DEG_SCF_FBW7_1	0.5633
p.S166N	DO229456	SKCA	ICGC	PETPDAS	DEG_SCF_FBW7_1	0.1944
p.L167F	SIDM00845	Burkitt's Lymphoma	GDSC	PETPDAS	DEG_SCF_FBW7_1	0.2222
p.L167F	ACH-000786	Lymphoma	CCLE	PETPDAS	DEG_SCF_FBW7_1	0.2222
p.L167F	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PETPDAS	DEG_SCF_FBW7_1	0.2222
p.S177I	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	PETPDAS	DEG_SCF_FBW7_1	0.7341
p.S177I	KYSE-410	oesophagus	COSMIC	PETPDAS	DEG_SCF_FBW7_1	0.7341
p.N166T	WM-115	skin	COSMIC	PETPDAS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11464	Pregnancy-specific beta-1-glycoprotein 1	DEG_SCF_FBW7_1	171:177	PETPDAS	FBXW7	0.8883	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PETPDAS

Degron related mutations and impact score

Drug responses associated with PSG1 mutations

All proteins holding degron of PETPDAS