DegronMD

Uniprot ID: Q9Y572

Source protein: Receptor-interacting serine/threonine-protein kinase 3

Source gene: RIPK3

Class: DEG_SCF_FBW7_2

Location: 250:256

E3 ligase: FBXW7

DEGRON score: 0.9126

ASA_SCORE: 71.1

COIL: 0.725

CONS_SCORE: 0.2502

DSS_SCORE: 0.5364

HELIX: 0.2443

FCONS_SCORE: 0.5496

RIG_SCORE: 0.6549

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W266C	TCGA-66-2771	LUSC	TCGA	PETPGLE	DEG_SCF_FBW7_2	0.0556
p.W266C	DO26870	LUSC	ICGC	PETPGLE	DEG_SCF_FBW7_2	0.0556
p.E251D	TCGA-EO-A3B0	UCEC	TCGA	PETPGLE	DEG_SCF_FBW7_2	0.5647
p.E251D	DO219773	UCEC	ICGC	PETPGLE	DEG_SCF_FBW7_2	0.5647
p.W266L	TCGA-FS-A1ZG	SKCM	TCGA	PETPGLE	DEG_SCF_FBW7_2	0.0556
p.W266L	DO37523	SKCM	ICGC	PETPGLE	DEG_SCF_FBW7_2	0.0556
p.E251Q	TCGA-K4-A6MB	BLCA	TCGA	PETPGLE	DEG_SCF_FBW7_2	0.5633
p.E251Q	DO44077	BLCA	ICGC	PETPGLE	DEG_SCF_FBW7_2	0.5633
p.L261I	DO229045	LICA	ICGC	PETPGLE	DEG_SCF_FBW7_2	0.1944
p.G254S	SIDM00251	Gastric Carcinoma	GDSC	PETPGLE	DEG_SCF_FBW7_2	0.5882
p.G254S	ACH-000949	Gastric Cancer	CCLE	PETPGLE	DEG_SCF_FBW7_2	0.5882
p.G254S	TGBC11TKB	stomach	COSMIC	PETPGLE	DEG_SCF_FBW7_2	0.5882
p.E260V	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PETPGLE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y572	Receptor-interacting serine/threonine-protein kinase 3	DEG_SCF_FBW7_2	250:256	PETPGLE	FBXW7	0.9126	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons