DegronMD

Uniprot ID: Q9Y3X0

Source protein: Coiled-coil domain-containing protein 9

Source gene: CCDC9

Class: DEG_SCF_FBW7_1

Location: 379:385

E3 ligase: FBXW7

DEGRON score: 0.9968

ASA_SCORE: 104.6429

COIL: 0.9479

CONS_SCORE: 0.4158

DSS_SCORE: 0.904

HELIX: 0.0207

FCONS_SCORE: 1.1372

RIG_SCORE: 0.4851

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P377T	TCGA-AA-3947	COAD	TCGA	PETPQPT	DEG_SCF_FBW7_1	0.2778
p.P377T	DO8192	COAD	ICGC	PETPQPT	DEG_SCF_FBW7_1	0.2778
p.P395S	DO41199	UCEC	ICGC	PETPQPT	DEG_SCF_FBW7_1	0.0556
p.A374V	ACH-000167	Myeloma	CCLE	PETPQPT	DEG_SCF_FBW7_1	0.1944
p.P387L	ACH-000394	Lung Cancer	CCLE	PETPQPT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3X0	Coiled-coil domain-containing protein 9	DEG_SCF_FBW7_1	379:385	PETPQPT	FBXW7	0.9968	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons