DegronMD

Uniprot ID: Q8WUY3

Source protein: Protein prune homolog 2

Source gene: PRUNE2

Class: DEG_SCF_FBW7_2

Location: 1951:1957

E3 ligase: FBXW7

DEGRON score: 0.9514

ASA_SCORE: 101.2429

COIL: 0.8374

CONS_SCORE: 0.3742

DSS_SCORE: 0.6231

HELIX: 0.1373

FCONS_SCORE: 1.0074

RIG_SCORE: 0.6887

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1942M	TCGA-37-4141	LUSC	TCGA	PETPTQE	DEG_SCF_FBW7_2	0.0833
p.A1944T	TCGA-55-6985	LUAD	TCGA	PETPTQE	DEG_SCF_FBW7_2	0.1389
p.A1944T	SIDM00217	Colorectal Carcinoma	GDSC	PETPTQE	DEG_SCF_FBW7_2	0.1389
p.A1944T	ACH-000999	Colon/Colorectal Cancer	CCLE	PETPTQE	DEG_SCF_FBW7_2	0.1389
p.A1944T	SNU-1040	large_intestine	COSMIC	PETPTQE	DEG_SCF_FBW7_2	0.1389
p.P1965L	TCGA-77-8150	LUSC	TCGA	PETPTQE	DEG_SCF_FBW7_2	0.1111
p.E1952K	TCGA-78-7156	LUAD	TCGA	PETPTQE	DEG_SCF_FBW7_2	0.591
p.E1952K	TCGA-ER-A195	SKCM	TCGA	PETPTQE	DEG_SCF_FBW7_2	0.591
p.M1963I	TCGA-DU-6392	LGG	TCGA	PETPTQE	DEG_SCF_FBW7_2	0.1667
p.Q1956K	TCGA-EE-A29P	SKCM	TCGA	PETPTQE	DEG_SCF_FBW7_2	0.5833
p.Q1956K	TCGA-EE-A3JB	SKCM	TCGA	PETPTQE	DEG_SCF_FBW7_2	0.5833
p.D1947N	TCGA-MP-A4TK	LUAD	TCGA	PETPTQE	DEG_SCF_FBW7_2	0.2222
p.H1942Q	DO1584	BRCA	ICGC	PETPTQE	DEG_SCF_FBW7_2	0.0833
p.S1943R	DO44454	HNSC	ICGC	PETPTQE	DEG_SCF_FBW7_2	0.1111
p.S1945R	DO229034	LICA	ICGC	PETPTQE	DEG_SCF_FBW7_2	0.1667
p.T1956A	DO22804	LICA	ICGC	PETPTQE	DEG_SCF_FBW7_2	0.7139
p.S1966F	DO37814	SKCM	ICGC	PETPTQE	DEG_SCF_FBW7_2	0.0833
p.S1966F	DO51276	SKCM	ICGC	PETPTQE	DEG_SCF_FBW7_2	0.0833
p.D1946N	DO50288	SKCM	ICGC	PETPTQE	DEG_SCF_FBW7_2	0.1944
p.D1946N	DO43306	UCEC	ICGC	PETPTQE	DEG_SCF_FBW7_2	0.1944
p.E1957D	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PETPTQE	DEG_SCF_FBW7_2	0.6758
p.E1957D	NB13	autonomic_ganglia	COSMIC	PETPTQE	DEG_SCF_FBW7_2	0.6758
p.G1949A	EKVX	lung	COSMIC	PETPTQE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WUY3	Protein prune homolog 2	DEG_SCF_FBW7_2	1951:1957	PETPTQE	FBXW7	0.9514	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons