DegronMD

Uniprot ID: Q08050

Source protein: Forkhead box protein M1

Source gene: FOXM1

Class: DEG_SCF_FBW7_2

Location: 597:604

E3 ligase: FBXW7

DEGRON score: 0.9979

ASA_SCORE: 81.6125

COIL: 0.7528

CONS_SCORE: 0.5729

DSS_SCORE: 0.5407

HELIX: 0.0499

FCONS_SCORE: 1.2854

RIG_SCORE: 0.6925

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L588I	TCGA-AX-A2HC	UCEC	TCGA	PFKTPIKE	DEG_SCF_FBW7_2	0.0833
p.L588I	DO41572	UCEC	ICGC	PFKTPIKE	DEG_SCF_FBW7_2	0.0833
p.S601L	TCGA-CR-6480	HNSC	TCGA	PFKTPIKE	DEG_SCF_FBW7_2	0.7667
p.S601L	DO14296	HNSC	ICGC	PFKTPIKE	DEG_SCF_FBW7_2	0.7667
p.L589P	DO44096	COAD	ICGC	PFKTPIKE	DEG_SCF_FBW7_2	0.1111
p.H587P	DO233140	GACA	ICGC	PFKTPIKE	DEG_SCF_FBW7_2	0.0556
p.L599F	SIDM00216	Colorectal Carcinoma	GDSC	PFKTPIKE	DEG_SCF_FBW7_2	0.6981
p.L599F	SNU-175	large_intestine	COSMIC	PFKTPIKE	DEG_SCF_FBW7_2	0.6981
p.P606T	ACH-000967	Colon/Colorectal Cancer	CCLE	PFKTPIKE	DEG_SCF_FBW7_2	0.2778
p.P603L	ACH-001550	Skin Cancer	CCLE	PFKTPIKE	DEG_SCF_FBW7_2	0.7582
p.P603L	MCC13	skin	COSMIC	PFKTPIKE	DEG_SCF_FBW7_2	0.7582
p.P603S	ACH-001550	Skin Cancer	CCLE	PFKTPIKE	DEG_SCF_FBW7_2	0.6752
p.P603S	MCC13	skin	COSMIC	PFKTPIKE	DEG_SCF_FBW7_2	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08050	Forkhead box protein M1	DEG_SCF_FBW7_2	597:604	PFKTPIKE	FBXW7	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons