DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PGCTPCPE
Uniprot ID:
Q96KN4
Source protein:
Protein LRATD1
Source gene:
LRATD1
Class:
DEG_SCF_FBW7_2
Location:
59:66
E3 ligase:
FBXW7
DEGRON score:
0.9699
ASA_SCORE:
82.6125
COIL:
0.9476
CONS_SCORE:
0.5809
DSS_SCORE:
0.5536
HELIX:
0.0223
FCONS_SCORE:
1.0149
RIG_SCORE:
0.5822
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R70H
SIDM01943
Colorectal Carcinoma
GDSC
PGCTPCPE
DEG_SCF_FBW7_2
0.2222
p.H71R
SIDM01246
Ewing's Sarcoma
GDSC
PGCTPCPE
DEG_SCF_FBW7_2
0.1944
Drug responses associated with LRATD1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PGCTPCPE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96KN4
Protein LRATD1
DEG_SCF_FBW7_2
59:66
PGCTPCPE
FBXW7
0.9699
More...