DegronMD

Uniprot ID: Q9Y6F6

Source protein: Inositol 1,4,5-triphosphate receptor associated 1

Source gene: IRAG1

Class: DEG_SCF_FBW7_1

Location: 702:709

E3 ligase: FBXW7

DEGRON score: 0.9722

ASA_SCORE: 76.5125

COIL: 0.9211

CONS_SCORE: 0.2779

DSS_SCORE: 0.4731

HELIX: 0.0515

FCONS_SCORE: 0.7195

RIG_SCORE: 0.6137

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P692S	SIDM01640	Acute Myeloid Leukemia	GDSC	PGQTPSSS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6F6	Inositol 1,4,5-triphosphate receptor associated 1	DEG_SCF_FBW7_1	702:709	PGQTPSSS	FBXW7	0.9722	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons