DegronMD

Uniprot ID: Q03431

Source protein: Parathyroid hormone/parathyroid hormone-related peptide receptor

Source gene: PTH1R

Class: DEG_SCF_FBW7_2

Location: 540:546

E3 ligase: FBXW7

DEGRON score: 0.6487

ASA_SCORE: 83.3143

COIL: 0.814

CONS_SCORE: 0.2738

DSS_SCORE: 0.7402

HELIX: 0.158

FCONS_SCORE: 0.8957

RIG_SCORE: 0.6377

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G536C	TCGA-06-1801	GBM	TCGA	PGTPALE	DEG_SCF_FBW7_2	0.2222
p.G536C	DO11986	GBM	ICGC	PGTPALE	DEG_SCF_FBW7_2	0.2222
p.E549K	TCGA-AP-A1E0	UCEC	TCGA	PGTPALE	DEG_SCF_FBW7_2	0.25
p.E549K	TCGA-E6-A1LX	UCEC	TCGA	PGTPALE	DEG_SCF_FBW7_2	0.25
p.E549K	DO41020	UCEC	ICGC	PGTPALE	DEG_SCF_FBW7_2	0.25
p.E549K	DO43154	UCEC	ICGC	PGTPALE	DEG_SCF_FBW7_2	0.25
p.H537Y	TCGA-EE-A29L	SKCM	TCGA	PGTPALE	DEG_SCF_FBW7_2	0.25
p.H537Y	TCGA-EE-A3AC	SKCM	TCGA	PGTPALE	DEG_SCF_FBW7_2	0.25
p.H537Y	DO37631	SKCM	ICGC	PGTPALE	DEG_SCF_FBW7_2	0.25
p.H537Y	DO37835	SKCM	ICGC	PGTPALE	DEG_SCF_FBW7_2	0.25
p.G530D	TCGA-ER-A193	SKCM	TCGA	PGTPALE	DEG_SCF_FBW7_2	0.0556
p.G530D	DO47368	SKCM	ICGC	PGTPALE	DEG_SCF_FBW7_2	0.0556
p.T547N	DO228531	LICA	ICGC	PGTPALE	DEG_SCF_FBW7_2	0.75
p.T547N	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	PGTPALE	DEG_SCF_FBW7_2	0.75
p.T547N	ACH-000917	Esophageal Cancer	CCLE	PGTPALE	DEG_SCF_FBW7_2	0.75
p.T547N	TE-4	oesophagus	COSMIC	PGTPALE	DEG_SCF_FBW7_2	0.75
p.G530V	DO228948	LICA	ICGC	PGTPALE	DEG_SCF_FBW7_2	0.0556
p.G536V	DO228952	LICA	ICGC	PGTPALE	DEG_SCF_FBW7_2	0.2222
p.A538S	DO229045	LICA	ICGC	PGTPALE	DEG_SCF_FBW7_2	0.2778
p.A556S	DO229045	LICA	ICGC	PGTPALE	DEG_SCF_FBW7_2	0.0556
p.T550A	DO220842	MELA	ICGC	PGTPALE	DEG_SCF_FBW7_2	0.2222
p.P532S	DO220906	MELA	ICGC	PGTPALE	DEG_SCF_FBW7_2	0.1111
p.G541E	SIDM00487	Colorectal Carcinoma	GDSC	PGTPALE	DEG_SCF_FBW7_2	0.6087
p.G541E	ACH-000963	Colon/Colorectal Cancer	CCLE	PGTPALE	DEG_SCF_FBW7_2	0.6087
p.G541E	CCK-81	large_intestine	COSMIC	PGTPALE	DEG_SCF_FBW7_2	0.6087
p.K539N	ACH-001032	Bone Cancer	CCLE	PGTPALE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03431	Parathyroid hormone/parathyroid hormone-related peptide receptor	DEG_SCF_FBW7_2	540:546	PGTPALE	FBXW7	0.6487	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons