DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PGTPQSS
Uniprot ID:
A6NCF6
Source protein:
Putative MAGE domain-containing protein MAGEA13P
Source gene:
MAGEA13P
Class:
DEG_SCF_FBW7_1
Location:
61:67
E3 ligase:
FBXW7
DEGRON score:
0.9394
ASA_SCORE:
70.9857
COIL:
0.894
CONS_SCORE:
0.2533
DSS_SCORE:
0.5594
HELIX:
0.056
FCONS_SCORE:
1.0358
RIG_SCORE:
0.6017
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MAGEA13P mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PGTPQSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NCF6
Putative MAGE domain-containing protein MAGEA13P
DEG_SCF_FBW7_1
61:67
PGTPQSS
FBXW7
0.9394
More...