DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PGTPYPE
Uniprot ID:
I3L273
Source protein:
Golgi-associated olfactory signaling regulator
Source gene:
GFY
Class:
DEG_SCF_FBW7_2
Location:
62:68
E3 ligase:
FBXW7
DEGRON score:
0.8976
ASA_SCORE:
90.9286
COIL:
0.9749
CONS_SCORE:
0
DSS_SCORE:
0.6868
HELIX:
0.0094
FCONS_SCORE:
0
RIG_SCORE:
0.5796
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.K53T
SIDM00878
Breast Carcinoma
GDSC
PGTPYPE
DEG_SCF_FBW7_2
0.1944
Drug responses associated with GFY mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PGTPYPE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
I3L273
Golgi-associated olfactory signaling regulator
DEG_SCF_FBW7_2
62:68
PGTPYPE
FBXW7
0.8976
More...