DegronMD

Uniprot ID: Q6ZVM7

Source protein: TOM1-like protein 2

Source gene: TOM1L2

Class: DEG_SCF_FBW7_1

Location: 161:168

E3 ligase: FBXW7

DEGRON score: 0.9985

ASA_SCORE: 100.3625

COIL: 0.9458

CONS_SCORE: 0.5231

DSS_SCORE: 0.5799

HELIX: 0.0248

FCONS_SCORE: 1.1243

RIG_SCORE: 0.6694

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V172L	TCGA-A5-A0G2	UCEC	TCGA	PIHTPQRS	DEG_SCF_FBW7_1	0.2222
p.A154T	TCGA-AA-3663	COAD	TCGA	PIHTPQRS	DEG_SCF_FBW7_1	0.1389
p.A154T	DO9346	COAD	ICGC	PIHTPQRS	DEG_SCF_FBW7_1	0.1389
p.S160A	TCGA-BR-A4J8	STAD	TCGA	PIHTPQRS	DEG_SCF_FBW7_1	0.75
p.S160A	DO38527	STAD	ICGC	PIHTPQRS	DEG_SCF_FBW7_1	0.75
p.L159V	TCGA-E5-A4TZ	BLCA	TCGA	PIHTPQRS	DEG_SCF_FBW7_1	0.2778
p.L159V	DO44055	BLCA	ICGC	PIHTPQRS	DEG_SCF_FBW7_1	0.2778
p.P158L	DO51939	BLCA	ICGC	PIHTPQRS	DEG_SCF_FBW7_1	0.25
p.P158L	DO41871	UCEC	ICGC	PIHTPQRS	DEG_SCF_FBW7_1	0.25
p.R167W	DO233903	GACA	ICGC	PIHTPQRS	DEG_SCF_FBW7_1	0.7523
p.A169D	DO229029	LICA	ICGC	PIHTPQRS	DEG_SCF_FBW7_1	0.3056
p.P165T	DO229038	LICA	ICGC	PIHTPQRS	DEG_SCF_FBW7_1	0.7031
p.A162D	DO229009	LICA	ICGC	PIHTPQRS	DEG_SCF_FBW7_1	0.7793
p.P161S	DO222810	MELA	ICGC	PIHTPQRS	DEG_SCF_FBW7_1	0.6752
p.A176V	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	PIHTPQRS	DEG_SCF_FBW7_1	0.1111
p.A176V	ACH-000647	Esophageal Cancer	CCLE	PIHTPQRS	DEG_SCF_FBW7_1	0.1111
p.A176V	TE-1	oesophagus	COSMIC	PIHTPQRS	DEG_SCF_FBW7_1	0.1111
p.R176K	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PIHTPQRS	DEG_SCF_FBW7_1	0.1111
p.A152T	C-33-A	cervix	COSMIC	PIHTPQRS	DEG_SCF_FBW7_1	0.0833
p.A157T	C-33-A	cervix	COSMIC	PIHTPQRS	DEG_SCF_FBW7_1	0.2222
p.R164Q	HCT-15	large_intestine	COSMIC	PIHTPQRS	DEG_SCF_FBW7_1	0.7329
p.L175P	MFE-319	endometrium	COSMIC	PIHTPQRS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZVM7	TOM1-like protein 2	DEG_SCF_FBW7_1	161:168	PIHTPQRS	FBXW7	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons