DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PILTPGHS
Uniprot ID:
P84996
Source protein:
Protein ALEX
Source gene:
GNAS
Class:
DEG_SCF_FBW7_1
Location:
356:363
E3 ligase:
FBXW7
DEGRON score:
0.8126
ASA_SCORE:
93.0375
COIL:
0.9584
CONS_SCORE:
0.3956
DSS_SCORE:
0.9047
HELIX:
0.0199
FCONS_SCORE:
0.9749
RIG_SCORE:
0.5492
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with GNAS mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PILTPGHS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P84996
Protein ALEX
DEG_SCF_FBW7_1
356:363
PILTPGHS
FBXW7
0.8126
More...