DegronMD

Uniprot ID: Q16513

Source protein: Serine/threonine-protein kinase N2

Source gene: PKN2

Class: DEG_SCF_FBW7_2

Location: 955:962

E3 ligase: FBXW7

DEGRON score: 0.9721

ASA_SCORE: 77.15

COIL: 0.9255

CONS_SCORE: 0.5188

DSS_SCORE: 0.5911

HELIX: 0.017

FCONS_SCORE: 0.9596

RIG_SCORE: 0.7295

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E970K	TCGA-22-5473	LUSC	TCGA	PILTPPRE	DEG_SCF_FBW7_2	0.1111
p.S967L	TCGA-AN-A046	BRCA	TCGA	PILTPPRE	DEG_SCF_FBW7_2	0.6389
p.S967L	SIDM00845	Burkitt's Lymphoma	GDSC	PILTPPRE	DEG_SCF_FBW7_2	0.6389
p.S967L	SIDM01519	Head and Neck Carcinoma	GDSC	PILTPPRE	DEG_SCF_FBW7_2	0.6389
p.R961Q	TCGA-E7-A7DU	BLCA	TCGA	PILTPPRE	DEG_SCF_FBW7_2	0.6218
p.N945K	ACH-000887	Brain Cancer	CCLE	PILTPPRE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16513	Serine/threonine-protein kinase N2	DEG_SCF_FBW7_2	955:962	PILTPPRE	FBXW7	0.9721	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons