DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PITPLGS
Uniprot ID:
Q96JP2
Source protein:
Unconventional myosin-XVB
Source gene:
MYO15B
Class:
DEG_SCF_FBW7_1
Location:
729:735
E3 ligase:
FBXW7
DEGRON score:
0.8511
ASA_SCORE:
45.2857
COIL:
0.7587
CONS_SCORE:
0.1458
DSS_SCORE:
0.5419
HELIX:
0.029
FCONS_SCORE:
0.6484
RIG_SCORE:
0.6812
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E737K
SiHa
cervix
COSMIC
PITPLGS
DEG_SCF_FBW7_1
0.2778
Drug responses associated with MYO15B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PITPLGS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96JP2
Unconventional myosin-XVB
DEG_SCF_FBW7_1
729:735
PITPLGS
FBXW7
0.8511
More...