DegronMD

Uniprot ID: Q9H171

Source protein: Z-DNA-binding protein 1

Source gene: ZBP1

Class: DEG_SCF_FBW7_1

Location: 384:390

E3 ligase: FBXW7

DEGRON score: 0.7051

ASA_SCORE: 72.4429

COIL: 0.7704

CONS_SCORE: 0.2647

DSS_SCORE: 0.7315

HELIX: 0.1463

FCONS_SCORE: 0.9218

RIG_SCORE: 0.6243

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R374I	TCGA-AN-A046	BRCA	TCGA	PITPSHS	DEG_SCF_FBW7_1	0.0556
p.R379Q	TCGA-DA-A1HY	SKCM	TCGA	PITPSHS	DEG_SCF_FBW7_1	0.1944
p.F385C	DO229010	COCA	ICGC	PITPSHS	DEG_SCF_FBW7_1	0.7108
p.F385C	DO229013	COCA	ICGC	PITPSHS	DEG_SCF_FBW7_1	0.7108
p.F385C	DO229016	COCA	ICGC	PITPSHS	DEG_SCF_FBW7_1	0.7108
p.F385C	DO229003	COCA	ICGC	PITPSHS	DEG_SCF_FBW7_1	0.7108
p.F385C	DO229005	COCA	ICGC	PITPSHS	DEG_SCF_FBW7_1	0.7108
p.S377L	DO15870	HNSC	ICGC	PITPSHS	DEG_SCF_FBW7_1	0.1389
p.P374S	DO222527	MELA	ICGC	PITPSHS	DEG_SCF_FBW7_1	0.0556
p.H376R	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PITPSHS	DEG_SCF_FBW7_1	0.1111
p.H376R	ACH-000766	Lung Cancer	CCLE	PITPSHS	DEG_SCF_FBW7_1	0.1111
p.H376R	NCI-H1648	lung	COSMIC	PITPSHS	DEG_SCF_FBW7_1	0.1111
p.S390L	SIDM01578	Bladder Carcinoma	GDSC	PITPSHS	DEG_SCF_FBW7_1	0.7667
p.S390L	ACH-000862	Bladder Cancer	CCLE	PITPSHS	DEG_SCF_FBW7_1	0.7667
p.S388R	ACH-001443	Thyroid Cancer	CCLE	PITPSHS	DEG_SCF_FBW7_1	0.6316

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H171	Z-DNA-binding protein 1	DEG_SCF_FBW7_1	384:390	PITPSHS	FBXW7	0.7051	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons