DegronMD

Uniprot ID: Q96EK4

Source protein: THAP domain-containing protein 11

Source gene: THAP11

Class: DEG_SCF_FBW7_2

Location: 177:183

E3 ligase: FBXW7

DEGRON score: 0.9732

ASA_SCORE: 79.3571

COIL: 0.8019

CONS_SCORE: 0.5435

DSS_SCORE: 0.5477

HELIX: 0.0274

FCONS_SCORE: 1.0271

RIG_SCORE: 0.6861

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P180A	TCGA-CR-6481	HNSC	TCGA	PITPTGE	DEG_SCF_FBW7_2	0.7503
p.P180A	DO14990	HNSC	ICGC	PITPTGE	DEG_SCF_FBW7_2	0.7503
p.S167R	DO225017	BRCA	ICGC	PITPTGE	DEG_SCF_FBW7_2	0.0556
p.P177H	DO229355	BTCA	ICGC	PITPTGE	DEG_SCF_FBW7_2	0.7694
p.V185L	DO229019	LICA	ICGC	PITPTGE	DEG_SCF_FBW7_2	0.2778
p.K186N	DO229019	LICA	ICGC	PITPTGE	DEG_SCF_FBW7_2	0.3611

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96EK4	THAP domain-containing protein 11	DEG_SCF_FBW7_2	177:183	PITPTGE	FBXW7	0.9732	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons