DegronMD

Uniprot ID: A0AV96

Source protein: RNA-binding protein 47

Source gene: RBM47

Class: DEG_SCF_FBW7_1

Location: 517:523

E3 ligase: FBXW7

DEGRON score: 0.9127

ASA_SCORE: 79.7

COIL: 0.9047

CONS_SCORE: 0.5547

DSS_SCORE: 0.3194

HELIX: 0.0133

FCONS_SCORE: 1.031

RIG_SCORE: 0.8087

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S508L	TCGA-AP-A1E0	UCEC	TCGA	PITPVYT	DEG_SCF_FBW7_1	0.5278
p.P517Q	TCGA-D3-A2JO	SKCM	TCGA	PITPVYT	DEG_SCF_FBW7_1	0.7035
p.P532S	TCGA-EE-A2MJ	SKCM	TCGA	PITPVYT	DEG_SCF_FBW7_1	0.0833
p.M527V	DO227999	COCA	ICGC	PITPVYT	DEG_SCF_FBW7_1	0.2222
p.M527V	DO229010	COCA	ICGC	PITPVYT	DEG_SCF_FBW7_1	0.2222
p.M527V	DO229013	COCA	ICGC	PITPVYT	DEG_SCF_FBW7_1	0.2222
p.M527V	DO229016	COCA	ICGC	PITPVYT	DEG_SCF_FBW7_1	0.2222
p.M527V	DO229003	COCA	ICGC	PITPVYT	DEG_SCF_FBW7_1	0.2222
p.M527V	DO228957	LICA	ICGC	PITPVYT	DEG_SCF_FBW7_1	0.2222
p.A515T	DO234214	ESAD	ICGC	PITPVYT	DEG_SCF_FBW7_1	0.2778
p.M527I	DO233097	GACA	ICGC	PITPVYT	DEG_SCF_FBW7_1	0.2222
p.P509S	DO44429	HNSC	ICGC	PITPVYT	DEG_SCF_FBW7_1	0.1111
p.T511K	DO228972	LICA	ICGC	PITPVYT	DEG_SCF_FBW7_1	0.1667
p.A532T	DO23390	LINC	ICGC	PITPVYT	DEG_SCF_FBW7_1	0.0833
p.G529R	DO45145	LIRI	ICGC	PITPVYT	DEG_SCF_FBW7_1	0.1667
p.A515S	DO230541	LUSC	ICGC	PITPVYT	DEG_SCF_FBW7_1	0.2778
p.Q518R	DO233298	NACA	ICGC	PITPVYT	DEG_SCF_FBW7_1	0.7329
p.G530E	DO229502	SKCA	ICGC	PITPVYT	DEG_SCF_FBW7_1	0.1389
p.N520S	DO38487	STAD	ICGC	PITPVYT	DEG_SCF_FBW7_1	0.7069
p.A524T	DO48016	STAD	ICGC	PITPVYT	DEG_SCF_FBW7_1	0.3056
p.A521V	DO229211	THCA	ICGC	PITPVYT	DEG_SCF_FBW7_1	0.6936
p.T513M	DO43186	UCEC	ICGC	PITPVYT	DEG_SCF_FBW7_1	0.2222
p.A508D	DO43819	UCEC	ICGC	PITPVYT	DEG_SCF_FBW7_1	0.5278
p.P511S	SIDM00770	Small Cell Lung Carcinoma	GDSC	PITPVYT	DEG_SCF_FBW7_1	0.1667
p.P511S	ACH-000559	Lung Cancer	CCLE	PITPVYT	DEG_SCF_FBW7_1	0.1667
p.P511S	NCI-H1836	lung	COSMIC	PITPVYT	DEG_SCF_FBW7_1	0.1667
p.T533A	SIDM00466	Ovarian Carcinoma	GDSC	PITPVYT	DEG_SCF_FBW7_1	0.5
p.T533A	SIDM00235	Kidney Carcinoma	GDSC	PITPVYT	DEG_SCF_FBW7_1	0.5
p.T533A	SIDM00488	Colorectal Carcinoma	GDSC	PITPVYT	DEG_SCF_FBW7_1	0.5
p.T533A	SIDM01377	Ovarian Carcinoma	GDSC	PITPVYT	DEG_SCF_FBW7_1	0.5
p.A525D	SIDM00217	Colorectal Carcinoma	GDSC	PITPVYT	DEG_SCF_FBW7_1	0.2778
p.A525D	ACH-000999	Colon/Colorectal Cancer	CCLE	PITPVYT	DEG_SCF_FBW7_1	0.2778
p.A525D	SNU-1040	large_intestine	COSMIC	PITPVYT	DEG_SCF_FBW7_1	0.2778
p.T509M	SIDM00861	Ovarian Carcinoma	GDSC	PITPVYT	DEG_SCF_FBW7_1	0.1111
p.T509M	ACH-000906	Ovarian Cancer	CCLE	PITPVYT	DEG_SCF_FBW7_1	0.1111
p.T509M	ES-2	ovary	COSMIC	PITPVYT	DEG_SCF_FBW7_1	0.1111
p.A524V	C-33-A	cervix	COSMIC	PITPVYT	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PITPVYT

Degron related mutations and impact score

Drug responses associated with RBM47 mutations

All proteins holding degron of PITPVYT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0AV96	RNA-binding protein 47	DEG_SCF_FBW7_1	517:523	PITPVYT	FBXW7	0.9127	More...