DegronMD

Uniprot ID: Q9UPV0

Source protein: Centrosomal protein of 164 kDa

Source gene: CEP164

Class: DEG_SCF_FBW7_1

Location: 1306:1313

E3 ligase: FBXW7

DEGRON score: 0.9765

ASA_SCORE: 72.6125

COIL: 0.9146

CONS_SCORE: 0.6811

DSS_SCORE: 0.6062

HELIX: 0.0388

FCONS_SCORE: 0.9777

RIG_SCORE: 0.6179

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1307N	TCGA-50-5049	LUAD	TCGA	PKSTPTPT	DEG_SCF_FBW7_1	0.5806
p.K1307N	DO23705	LUAD	ICGC	PKSTPTPT	DEG_SCF_FBW7_1	0.5806
p.A1299T	TCGA-AZ-6598	COAD	TCGA	PKSTPTPT	DEG_SCF_FBW7_1	0.1389
p.A1299T	DO10276	COAD	ICGC	PKSTPTPT	DEG_SCF_FBW7_1	0.1389
p.A1319S	TCGA-BS-A0UF	UCEC	TCGA	PKSTPTPT	DEG_SCF_FBW7_1	0.1667
p.A1319S	DO41488	UCEC	ICGC	PKSTPTPT	DEG_SCF_FBW7_1	0.1667
p.S1296F	TCGA-FS-A1Z3	SKCM	TCGA	PKSTPTPT	DEG_SCF_FBW7_1	0.0556
p.S1296F	DO37635	SKCM	ICGC	PKSTPTPT	DEG_SCF_FBW7_1	0.0556
p.G1316D	TCGA-HU-A4G8	STAD	TCGA	PKSTPTPT	DEG_SCF_FBW7_1	0.25
p.G1316D	DO47819	STAD	ICGC	PKSTPTPT	DEG_SCF_FBW7_1	0.25
p.P1303T	TCGA-NJ-A55A	LUAD	TCGA	PKSTPTPT	DEG_SCF_FBW7_1	0.25
p.P1303T	DO218945	LUAD	ICGC	PKSTPTPT	DEG_SCF_FBW7_1	0.25
p.D1305N	TCGA-XF-A9SX	BLCA	TCGA	PKSTPTPT	DEG_SCF_FBW7_1	0.3056
p.D1305N	DO51916	BLCA	ICGC	PKSTPTPT	DEG_SCF_FBW7_1	0.3056
p.T1313P	DO229259	THCA	ICGC	PKSTPTPT	DEG_SCF_FBW7_1	0.7031
p.T1311P	DO229221	THCA	ICGC	PKSTPTPT	DEG_SCF_FBW7_1	0.5919
p.T1311S	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	PKSTPTPT	DEG_SCF_FBW7_1	0.6005
p.T1311S	SIDM00845	Burkitt's Lymphoma	GDSC	PKSTPTPT	DEG_SCF_FBW7_1	0.6005
p.T1311S	SIDM00656	Burkitt's Lymphoma	GDSC	PKSTPTPT	DEG_SCF_FBW7_1	0.6005
p.T1311S	SIDM00210	Ovarian Carcinoma	GDSC	PKSTPTPT	DEG_SCF_FBW7_1	0.6005
p.T1311S	SIDM00849	Kidney Carcinoma	GDSC	PKSTPTPT	DEG_SCF_FBW7_1	0.6005
p.T1311S	SIDM00309	Mesothelioma	GDSC	PKSTPTPT	DEG_SCF_FBW7_1	0.6005
p.T1311S	SIDM01147	Gastric Carcinoma	GDSC	PKSTPTPT	DEG_SCF_FBW7_1	0.6005
p.T1311S	SIDM00863	Burkitt's Lymphoma	GDSC	PKSTPTPT	DEG_SCF_FBW7_1	0.6005
p.T1311S	SIDM00785	Acute Myeloid Leukemia	GDSC	PKSTPTPT	DEG_SCF_FBW7_1	0.6005
p.T1311S	SIDM00641	Burkitt's Lymphoma	GDSC	PKSTPTPT	DEG_SCF_FBW7_1	0.6005
p.T1311S	SIDM01409	Bladder Carcinoma	GDSC	PKSTPTPT	DEG_SCF_FBW7_1	0.6005
p.D1305Y	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PKSTPTPT	DEG_SCF_FBW7_1	0.3056
p.D1305Y	H513	pleura	COSMIC	PKSTPTPT	DEG_SCF_FBW7_1	0.3056
p.A1319T	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	PKSTPTPT	DEG_SCF_FBW7_1	0.1667
p.A1319T	ACH-000343	Lung Cancer	CCLE	PKSTPTPT	DEG_SCF_FBW7_1	0.1667
p.A1319T	NCI-H522	lung	COSMIC	PKSTPTPT	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKSTPTPT

Degron related mutations and impact score

Drug responses associated with CEP164 mutations

All proteins holding degron of PKSTPTPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPV0	Centrosomal protein of 164 kDa	DEG_SCF_FBW7_1	1306:1313	PKSTPTPT	FBXW7	0.9765	More...