DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PKTPSLS
Uniprot ID:
Q9H1K0
Source protein:
Rabenosyn-5
Source gene:
RBSN
Class:
DEG_SCF_FBW7_1
Location:
586:592
E3 ligase:
FBXW7
DEGRON score:
0.9745
ASA_SCORE:
93
COIL:
0.9446
CONS_SCORE:
0.3838
DSS_SCORE:
0.6935
HELIX:
0.0256
FCONS_SCORE:
0.989
RIG_SCORE:
0.5789
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with RBSN mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PKTPSLS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H1K0
Rabenosyn-5
DEG_SCF_FBW7_1
586:592
PKTPSLS
FBXW7
0.9745
More...