DegronMD

Uniprot ID: Q92835

Source protein: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

Source gene: INPP5D

Class: DEG_SCF_FBW7_1

Location: 1106:1112

E3 ligase: FBXW7

DEGRON score: 0.9706

ASA_SCORE: 91.6286

COIL: 0.9404

CONS_SCORE: 0.3166

DSS_SCORE: 0.7929

HELIX: 0.035

FCONS_SCORE: 1.0027

RIG_SCORE: 0.5855

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1104E	SIDM00853	Other Sarcomas	GDSC	PKTPVSS	DEG_SCF_FBW7_1	0.2778
p.G1104E	GCT	soft_tissue	COSMIC	PKTPVSS	DEG_SCF_FBW7_1	0.2778
p.P1115L	SIDM00210	Ovarian Carcinoma	GDSC	PKTPVSS	DEG_SCF_FBW7_1	0.25
p.P1103L	ACH-000657	Ovarian Cancer	CCLE	PKTPVSS	DEG_SCF_FBW7_1	0.25
p.G1103E	GCT	soft_tissue	COSMIC	PKTPVSS	DEG_SCF_FBW7_1	0.25
p.N1118Y	ACH-000968	Skin Cancer	CCLE	PKTPVSS	DEG_SCF_FBW7_1	0.1667

Showing 1 to 6 of 6 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92835	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1	DEG_SCF_FBW7_1	1106:1112	PKTPVSS	FBXW7	0.9706	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons