DegronMD

Uniprot ID: A2RUB1

Source protein: Meiosis-specific coiled-coil domain-containing protein MEIOC

Source gene: MEIOC

Class: DEG_SCF_FBW7_1

Location: 395:402

E3 ligase: FBXW7

DEGRON score: 0.9928

ASA_SCORE: 81.6

COIL: 0.87

CONS_SCORE: 0.6017

DSS_SCORE: 0.5023

HELIX: 0.0941

FCONS_SCORE: 0.9738

RIG_SCORE: 0.75

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V411A	SIDM00845	Burkitt's Lymphoma	GDSC	PKTTPHLT	DEG_SCF_FBW7_1	0.0833
p.I386V	SIDM00333	Endometrial Carcinoma	GDSC	PKTTPHLT	DEG_SCF_FBW7_1	0.0833
p.I386V	MFE-319	endometrium	COSMIC	PKTTPHLT	DEG_SCF_FBW7_1	0.0833
p.T398M	SIDM01770	Gastric Carcinoma	GDSC	PKTTPHLT	DEG_SCF_FBW7_1	0.7423
p.A410G	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	PKTTPHLT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2RUB1	Meiosis-specific coiled-coil domain-containing protein MEIOC	DEG_SCF_FBW7_1	395:402	PKTTPHLT	FBXW7	0.9928	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons