DegronMD

Uniprot ID: O43765

Source protein: Small glutamine-rich tetratricopeptide repeat-containing protein alpha

Source gene: SGTA

Class: DEG_SCF_FBW7_1

Location: 257:264

E3 ligase: FBXW7

DEGRON score: 0.963

ASA_SCORE: 65.2125

COIL: 0.9283

CONS_SCORE: 0.2763

DSS_SCORE: 0.7068

HELIX: 0.0383

FCONS_SCORE: 0.7532

RIG_SCORE: 0.5541

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D269E	TCGA-AP-A1DK	UCEC	TCGA	PLGTPGTS	DEG_SCF_FBW7_1	0.1944
p.D269E	DO42033	UCEC	ICGC	PLGTPGTS	DEG_SCF_FBW7_1	0.1944
p.M247R	TCGA-AX-A2IN	UCEC	TCGA	PLGTPGTS	DEG_SCF_FBW7_1	0.0556
p.M247R	DO42328	UCEC	ICGC	PLGTPGTS	DEG_SCF_FBW7_1	0.0556
p.S252L	TCGA-B5-A1MR	UCEC	TCGA	PLGTPGTS	DEG_SCF_FBW7_1	0.1944
p.S252L	TCGA-EO-A22X	UCEC	TCGA	PLGTPGTS	DEG_SCF_FBW7_1	0.1944
p.S252L	TCGA-EO-A3B0	UCEC	TCGA	PLGTPGTS	DEG_SCF_FBW7_1	0.1944
p.S252L	TCGA-K1-A6RT	SARC	TCGA	PLGTPGTS	DEG_SCF_FBW7_1	0.1944
p.S252L	TCGA-KN-8428	KICH	TCGA	PLGTPGTS	DEG_SCF_FBW7_1	0.1944
p.S252L	DO220484	KICH	ICGC	PLGTPGTS	DEG_SCF_FBW7_1	0.1944
p.S252L	DO220875	MELA	ICGC	PLGTPGTS	DEG_SCF_FBW7_1	0.1944
p.S252L	DO220193	SARC	ICGC	PLGTPGTS	DEG_SCF_FBW7_1	0.1944
p.S252L	DO219773	UCEC	ICGC	PLGTPGTS	DEG_SCF_FBW7_1	0.1944
p.S252L	DO41758	UCEC	ICGC	PLGTPGTS	DEG_SCF_FBW7_1	0.1944
p.S252L	DO43907	UCEC	ICGC	PLGTPGTS	DEG_SCF_FBW7_1	0.1944
p.G262V	TCGA-CR-7364	HNSC	TCGA	PLGTPGTS	DEG_SCF_FBW7_1	0.6421
p.G262V	DO15679	HNSC	ICGC	PLGTPGTS	DEG_SCF_FBW7_1	0.6421
p.G262C	TCGA-CR-7364	HNSC	TCGA	PLGTPGTS	DEG_SCF_FBW7_1	0.6489
p.G262C	DO15679	HNSC	ICGC	PLGTPGTS	DEG_SCF_FBW7_1	0.6489
p.S264I	DO234329	ESAD	ICGC	PLGTPGTS	DEG_SCF_FBW7_1	0.7341
p.N268K	DO228978	LICA	ICGC	PLGTPGTS	DEG_SCF_FBW7_1	0.2222
p.L270M	DO228985	LICA	ICGC	PLGTPGTS	DEG_SCF_FBW7_1	0.1667
p.S264R	DO229019	LICA	ICGC	PLGTPGTS	DEG_SCF_FBW7_1	0.7427
p.Q267K	DO229037	LICA	ICGC	PLGTPGTS	DEG_SCF_FBW7_1	0.25
p.A271D	DO229009	LICA	ICGC	PLGTPGTS	DEG_SCF_FBW7_1	0.1389
p.D269N	DO36556	READ	ICGC	PLGTPGTS	DEG_SCF_FBW7_1	0.1944
p.L273I	ACH-001699	Head and Neck Cancer	CCLE	PLGTPGTS	DEG_SCF_FBW7_1	0.0833
p.D269G	ACH-001786	Colon/Colorectal Cancer	CCLE	PLGTPGTS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43765	Small glutamine-rich tetratricopeptide repeat-containing protein alpha	DEG_SCF_FBW7_1	257:264	PLGTPGTS	FBXW7	0.963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLGTPGTS

Degron related mutations and impact score

Drug responses associated with SGTA mutations

All proteins holding degron of PLGTPGTS