DegronMD

Uniprot ID: Q5TD94

Source protein: Radial spoke head protein 4 homolog A

Source gene: RSPH4A

Class: DEG_SCF_FBW7_2

Location: 590:597

E3 ligase: FBXW7

DEGRON score: 0.9959

ASA_SCORE: 70.7375

COIL: 0.8373

CONS_SCORE: 0.6466

DSS_SCORE: 0.4165

HELIX: 0.0733

FCONS_SCORE: 1.2485

RIG_SCORE: 0.7868

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G584C	DO1697	BRCA	ICGC	PLLTPISE	DEG_SCF_FBW7_2	0.1667
p.G584C	DO229038	LICA	ICGC	PLLTPISE	DEG_SCF_FBW7_2	0.1667
p.E586K	DO1285	BRCA	ICGC	PLLTPISE	DEG_SCF_FBW7_2	0.2222
p.A593T	DO228138	PBCA	ICGC	PLLTPISE	DEG_SCF_FBW7_2	0.7139
p.S595R	DO36556	READ	ICGC	PLLTPISE	DEG_SCF_FBW7_2	0.7427
p.I598M	DO50075	UCEC	ICGC	PLLTPISE	DEG_SCF_FBW7_2	0.3056
p.M588I	DO42472	UCEC	ICGC	PLLTPISE	DEG_SCF_FBW7_2	0.2778
p.E584K	SIDM00225	Melanoma	GDSC	PLLTPISE	DEG_SCF_FBW7_2	0.1667
p.E584K	ACH-002143	Skin Cancer	CCLE	PLLTPISE	DEG_SCF_FBW7_2	0.1667
p.E584K	IST-MEL1	skin	COSMIC	PLLTPISE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TD94	Radial spoke head protein 4 homolog A	DEG_SCF_FBW7_2	590:597	PLLTPISE	FBXW7	0.9959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons