DegronMD

Uniprot ID: Q9BYW2

Source protein: Histone-lysine N-methyltransferase SETD2

Source gene: SETD2

Class: DEG_SCF_FBW7_1

Location: 1854:1861

E3 ligase: FBXW7

DEGRON score: 0.9652

ASA_SCORE: 90.625

COIL: 0.9113

CONS_SCORE: 0.3781

DSS_SCORE: 0.7029

HELIX: 0.06

FCONS_SCORE: 1.0219

RIG_SCORE: 0.5966

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1849L	TCGA-B5-A0JY	UCEC	TCGA	PLNTPDPS	DEG_SCF_FBW7_1	0.6389
p.S1849L	TCGA-VQ-A8P2	STAD	TCGA	PLNTPDPS	DEG_SCF_FBW7_1	0.6389
p.S1849L	DO234255	ESAD	ICGC	PLNTPDPS	DEG_SCF_FBW7_1	0.6389
p.S1849L	DO51761	STAD	ICGC	PLNTPDPS	DEG_SCF_FBW7_1	0.6389
p.S1849L	DO43041	UCEC	ICGC	PLNTPDPS	DEG_SCF_FBW7_1	0.6389
p.S1849L	ACH-000686	Liver Cancer	CCLE	PLNTPDPS	DEG_SCF_FBW7_1	0.6389
p.D1869V	TCGA-BP-4963	KIRC	TCGA	PLNTPDPS	DEG_SCF_FBW7_1	0.1111
p.D1869V	DO20653	KIRC	ICGC	PLNTPDPS	DEG_SCF_FBW7_1	0.1111
p.R1850C	TCGA-E1-A7YK	LGG	TCGA	PLNTPDPS	DEG_SCF_FBW7_1	0.2222
p.R1850C	DO219793	LGG	ICGC	PLNTPDPS	DEG_SCF_FBW7_1	0.2222
p.N1847S	TCGA-NC-A5HM	LUSC	TCGA	PLNTPDPS	DEG_SCF_FBW7_1	0.1389
p.N1847S	DO219195	LUSC	ICGC	PLNTPDPS	DEG_SCF_FBW7_1	0.1389
p.S1865I	DO222479	BTCA	ICGC	PLNTPDPS	DEG_SCF_FBW7_1	0.2222
p.P1860S	DO233686	GACA	ICGC	PLNTPDPS	DEG_SCF_FBW7_1	0.5641
p.D1871E	DO229045	LICA	ICGC	PLNTPDPS	DEG_SCF_FBW7_1	0.0556
p.P1858H	SIDM00577	Neuroblastoma	GDSC	PLNTPDPS	DEG_SCF_FBW7_1	0.7694
p.P1858H	ACH-001603	Neuroblastoma	CCLE	PLNTPDPS	DEG_SCF_FBW7_1	0.7694
p.P1858H	NH-12	autonomic_ganglia	COSMIC	PLNTPDPS	DEG_SCF_FBW7_1	0.7694

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BYW2	Histone-lysine N-methyltransferase SETD2	DEG_SCF_FBW7_1	1854:1861	PLNTPDPS	FBXW7	0.9652	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons