DegronMD

Uniprot ID: P23468

Source protein: Receptor-type tyrosine-protein phosphatase delta

Source gene: PTPRD

Class: DEG_SCF_FBW7_2

Location: 86:93

E3 ligase: FBXW7

DEGRON score: 0.833

ASA_SCORE: 81.2125

COIL: 0.6849

CONS_SCORE: 0.5769

DSS_SCORE: 0.2924

HELIX: 0.1099

FCONS_SCORE: 0.8976

RIG_SCORE: 0.7924

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D76N	TCGA-44-3918	LUAD	TCGA	PLRTPRDE	DEG_SCF_FBW7_2	0.0556
p.D76N	DO23732	LUAD	ICGC	PLRTPRDE	DEG_SCF_FBW7_2	0.0556
p.A100D	TCGA-75-6214	LUAD	TCGA	PLRTPRDE	DEG_SCF_FBW7_2	0.1389
p.A100D	DO24830	LUAD	ICGC	PLRTPRDE	DEG_SCF_FBW7_2	0.1389
p.L82I	TCGA-A5-A2K5	UCEC	TCGA	PLRTPRDE	DEG_SCF_FBW7_2	0.2222
p.L82I	DO41379	UCEC	ICGC	PLRTPRDE	DEG_SCF_FBW7_2	0.2222
p.L82I	SIDM01611	Endometrial Carcinoma	GDSC	PLRTPRDE	DEG_SCF_FBW7_2	0.2222
p.L82I	ACH-000996	Endometrial/Uterine Cancer	CCLE	PLRTPRDE	DEG_SCF_FBW7_2	0.2222
p.E93K	TCGA-AO-A0JC	BRCA	TCGA	PLRTPRDE	DEG_SCF_FBW7_2	0.7022
p.E93K	DO5277	BRCA	ICGC	PLRTPRDE	DEG_SCF_FBW7_2	0.7022
p.I84M	TCGA-BT-A42E	BLCA	TCGA	PLRTPRDE	DEG_SCF_FBW7_2	0.2778
p.I84M	DO44030	BLCA	ICGC	PLRTPRDE	DEG_SCF_FBW7_2	0.2778
p.G77V	TCGA-CN-A63T	HNSC	TCGA	PLRTPRDE	DEG_SCF_FBW7_2	0.0833
p.G77V	DO49040	HNSC	ICGC	PLRTPRDE	DEG_SCF_FBW7_2	0.0833
p.A100S	TCGA-CV-A45Z	HNSC	TCGA	PLRTPRDE	DEG_SCF_FBW7_2	0.1389
p.A100S	DO52064	HNSC	ICGC	PLRTPRDE	DEG_SCF_FBW7_2	0.1389
p.A100V	TCGA-DU-6407	LGG	TCGA	PLRTPRDE	DEG_SCF_FBW7_2	0.1389
p.A100V	DO22295	LGG	ICGC	PLRTPRDE	DEG_SCF_FBW7_2	0.1389
p.S80L	TCGA-EE-A3J4	SKCM	TCGA	PLRTPRDE	DEG_SCF_FBW7_2	0.1667
p.S80L	TCGA-FR-A726	SKCM	TCGA	PLRTPRDE	DEG_SCF_FBW7_2	0.1667
p.S80L	DO48665	SKCM	ICGC	PLRTPRDE	DEG_SCF_FBW7_2	0.1667
p.S80L	DO48604	SKCM	ICGC	PLRTPRDE	DEG_SCF_FBW7_2	0.1667
p.P90S	TCGA-ER-A193	SKCM	TCGA	PLRTPRDE	DEG_SCF_FBW7_2	0.6752
p.P90S	DO229462	SKCA	ICGC	PLRTPRDE	DEG_SCF_FBW7_2	0.6752
p.P90S	DO47368	SKCM	ICGC	PLRTPRDE	DEG_SCF_FBW7_2	0.6752
p.D92H	TCGA-FD-A3SO	BLCA	TCGA	PLRTPRDE	DEG_SCF_FBW7_2	0.6577
p.D92H	DO569	BLCA	ICGC	PLRTPRDE	DEG_SCF_FBW7_2	0.6577
p.R91K	TCGA-FI-A2D0	UCEC	TCGA	PLRTPRDE	DEG_SCF_FBW7_2	0.6126
p.R91K	DO43891	UCEC	ICGC	PLRTPRDE	DEG_SCF_FBW7_2	0.6126
p.A94V	TCGA-ZF-A9RF	BLCA	TCGA	PLRTPRDE	DEG_SCF_FBW7_2	0.3056
p.A94V	DO219074	BLCA	ICGC	PLRTPRDE	DEG_SCF_FBW7_2	0.3056
p.A94V	DO233109	GACA	ICGC	PLRTPRDE	DEG_SCF_FBW7_2	0.3056
p.N103D	DO234334	ESAD	ICGC	PLRTPRDE	DEG_SCF_FBW7_2	0.0556
p.A100T	DO220879	MELA	ICGC	PLRTPRDE	DEG_SCF_FBW7_2	0.1389
p.E97K	DO222868	MELA	ICGC	PLRTPRDE	DEG_SCF_FBW7_2	0.2222
p.P90L	DO230449	UTCA	ICGC	PLRTPRDE	DEG_SCF_FBW7_2	0.7582
p.R83S	SIDM00683	Prostate Carcinoma	GDSC	PLRTPRDE	DEG_SCF_FBW7_2	0.25
p.R83S	ACH-000977	lymph_node	CCLE	PLRTPRDE	DEG_SCF_FBW7_2	0.25
p.R83S	LNCaP-Clone-FGC	prostate	COSMIC	PLRTPRDE	DEG_SCF_FBW7_2	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLRTPRDE

Degron related mutations and impact score

Drug responses associated with PTPRD mutations

All proteins holding degron of PLRTPRDE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23468	Receptor-type tyrosine-protein phosphatase delta	DEG_SCF_FBW7_2	86:93	PLRTPRDE	FBXW7	0.833	More...