DegronMD

Uniprot ID: C9JUS6

Source protein: Putative adrenomedullin-5-like protein

Source gene: ADM5

Class: DEG_SCF_FBW7_2

Location: 136:142

E3 ligase: FBXW7

DEGRON score: 0.7998

ASA_SCORE: 90.9857

COIL: 0.9304

CONS_SCORE: 0

DSS_SCORE: 0.306

HELIX: 0.0186

FCONS_SCORE: 0

RIG_SCORE: 0.671

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S134F	TCGA-AX-A2HC	UCEC	TCGA	PLTPAPE	DEG_SCF_FBW7_2	0.2778
p.S134F	DO41572	UCEC	ICGC	PLTPAPE	DEG_SCF_FBW7_2	0.2778
p.F145L	TCGA-CC-A8HV	LIHC	TCGA	PLTPAPE	DEG_SCF_FBW7_2	0.25
p.F145L	DO52189	LIHC	ICGC	PLTPAPE	DEG_SCF_FBW7_2	0.25
p.V144I	DO228961	LICA	ICGC	PLTPAPE	DEG_SCF_FBW7_2	0.2778
p.I133T	ACH-001060	Lymphoma	CCLE	PLTPAPE	DEG_SCF_FBW7_2	0.25
p.L131F	ACH-001354	Neuroblastoma	CCLE	PLTPAPE	DEG_SCF_FBW7_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
C9JUS6	Putative adrenomedullin-5-like protein	DEG_SCF_FBW7_2	136:142	PLTPAPE	FBXW7	0.7998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons