DegronMD

Uniprot ID: P10826

Source protein: Retinoic acid receptor beta

Source gene: RARB

Class: DEG_SCF_FBW7_1

Location: 422:428

E3 ligase: FBXW7

DEGRON score: 0.9408

ASA_SCORE: 85.7143

COIL: 0.9559

CONS_SCORE: 0.1993

DSS_SCORE: 0.7865

HELIX: 0.0277

FCONS_SCORE: 0.6532

RIG_SCORE: 0.5437

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N423I	TCGA-A8-A081	BRCA	TCGA	PLTPSSS	DEG_SCF_FBW7_1	0.728
p.E437Q	TCGA-DK-AA71	BLCA	TCGA	PLTPSSS	DEG_SCF_FBW7_1	0.0833
p.N430I	DO2943	BRCA	ICGC	PLTPSSS	DEG_SCF_FBW7_1	0.2778
p.T424I	SIDM00845	Burkitt's Lymphoma	GDSC	PLTPSSS	DEG_SCF_FBW7_1	0.7078
p.T424I	SIDM00461	Acute Myeloid Leukemia	GDSC	PLTPSSS	DEG_SCF_FBW7_1	0.7078
p.T424I	SIDM01519	Head and Neck Carcinoma	GDSC	PLTPSSS	DEG_SCF_FBW7_1	0.7078
p.T424I	ACH-000786	Lymphoma	CCLE	PLTPSSS	DEG_SCF_FBW7_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10826	Retinoic acid receptor beta	DEG_SCF_FBW7_1	422:428	PLTPSSS	FBXW7	0.9408	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons