DegronMD

Uniprot ID: O95180

Source protein: Voltage-dependent T-type calcium channel subunit alpha-1H

Source gene: CACNA1H

Class: DEG_SCF_FBW7_1

Location: 1084:1091

E3 ligase: FBXW7

DEGRON score: 0.9968

ASA_SCORE: 78.35

COIL: 0.909

CONS_SCORE: 0.3679

DSS_SCORE: 0.5541

HELIX: 0.0409

FCONS_SCORE: 0.9226

RIG_SCORE: 0.6428

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1093L	DO229056	LICA	ICGC	PMPTPKSS	DEG_SCF_FBW7_1	0.2778
p.A1096V	DO23466	LINC	ICGC	PMPTPKSS	DEG_SCF_FBW7_1	0.1944
p.M1085I	DO33105	PACA	ICGC	PMPTPKSS	DEG_SCF_FBW7_1	0.6507
p.P1086H	DO229232	THCA	ICGC	PMPTPKSS	DEG_SCF_FBW7_1	0.6583
p.A1097T	DO229248	THCA	ICGC	PMPTPKSS	DEG_SCF_FBW7_1	0.1667
p.A1081T	SIDM00392	Melanoma	GDSC	PMPTPKSS	DEG_SCF_FBW7_1	0.25
p.A1081T	ACH-000810	Skin Cancer	CCLE	PMPTPKSS	DEG_SCF_FBW7_1	0.25
p.A1081T	SK-MEL-30	skin	COSMIC	PMPTPKSS	DEG_SCF_FBW7_1	0.25
p.P1088L	ACH-000572	Skin Cancer	CCLE	PMPTPKSS	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95180	Voltage-dependent T-type calcium channel subunit alpha-1H	DEG_SCF_FBW7_1	1084:1091	PMPTPKSS	FBXW7	0.9968	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons