DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PMTTPPTS
Uniprot ID:
Q6ICC9
Source protein:
Retrotransposon Gag-like protein 6
Source gene:
RTL6
Class:
DEG_SCF_FBW7_1
Location:
93:100
E3 ligase:
FBXW7
DEGRON score:
0.8531
ASA_SCORE:
86.475
COIL:
0.96
CONS_SCORE:
1
DSS_SCORE:
0.7415
HELIX:
0.0128
FCONS_SCORE:
1.0166
RIG_SCORE:
0.6181
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with RTL6 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PMTTPPTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6ICC9
Retrotransposon Gag-like protein 6
DEG_SCF_FBW7_1
93:100
PMTTPPTS
FBXW7
0.8531
More...