DegronMD

Uniprot ID: Q9BUX1

Source protein: Glutathione-specific gamma-glutamylcyclotransferase 1

Source gene: CHAC1

Class: DEG_SCF_FBW7_1

Location: 8:14

E3 ligase: FBXW7

DEGRON score: 0.5121

ASA_SCORE: 92.8857

COIL: 0.9636

CONS_SCORE: -285.3338

DSS_SCORE: 0.8887

HELIX: 0.0277

FCONS_SCORE: 0.7343

RIG_SCORE: 0.5284

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V18F	DO229035	LICA	ICGC	PNTPPTS	DEG_SCF_FBW7_1	0.2222
p.Q9H	DO51189	LUAD	ICGC	PNTPPTS	DEG_SCF_FBW7_1	0.7582
p.L6P	DO232846	NACA	ICGC	PNTPPTS	DEG_SCF_FBW7_1	0.2778
p.V17A	DO42023	UCEC	ICGC	PNTPPTS	DEG_SCF_FBW7_1	0.25
p.P14S	SIDM02021	Esophageal Carcinoma	GDSC	PNTPPTS	DEG_SCF_FBW7_1	0.6752
p.R23C	ACH-000997	Colon/Colorectal Cancer	CCLE	PNTPPTS	DEG_SCF_FBW7_1	0.0833
p.H12Y	EC-GI-10	oesophagus	COSMIC	PNTPPTS	DEG_SCF_FBW7_1	0.7229
p.R13G	EW-24	bone	COSMIC	PNTPPTS	DEG_SCF_FBW7_1	0.7568
p.Q7R	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PNTPPTS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BUX1	Glutathione-specific gamma-glutamylcyclotransferase 1	DEG_SCF_FBW7_1	8:14	PNTPPTS	FBXW7	0.5121	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons