DegronMD

Uniprot ID: Q9Y662

Source protein: Heparan sulfate glucosamine 3-O-sulfotransferase 3B1

Source gene: HS3ST3B1

Class: DEG_SCF_FBW7_1

Location: 93:100

E3 ligase: FBXW7

DEGRON score: 0.8886

ASA_SCORE: 75.7375

COIL: 0.8695

CONS_SCORE: 0.5585

DSS_SCORE: 0.7172

HELIX: 0.0927

FCONS_SCORE: 1.0149

RIG_SCORE: 0.6068

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G83R	SIDM00875	Breast Carcinoma	GDSC	PPATPLAS	DEG_SCF_FBW7_1	0.0556
p.G107A	SIDM00898	Breast Carcinoma	GDSC	PPATPLAS	DEG_SCF_FBW7_1	0.1389
p.G107A	ACH-000017	Breast Cancer	CCLE	PPATPLAS	DEG_SCF_FBW7_1	0.1389
p.G107A	ACH-000248	Breast Cancer	CCLE	PPATPLAS	DEG_SCF_FBW7_1	0.1389
p.G107A	AU565	breast	COSMIC	PPATPLAS	DEG_SCF_FBW7_1	0.1389
p.S110I	SIDM00217	Colorectal Carcinoma	GDSC	PPATPLAS	DEG_SCF_FBW7_1	0.0556
p.S110I	ACH-000999	Colon/Colorectal Cancer	CCLE	PPATPLAS	DEG_SCF_FBW7_1	0.0556
p.S110I	SNU-1040	large_intestine	COSMIC	PPATPLAS	DEG_SCF_FBW7_1	0.0556
p.R87M	SIDM00901	Endometrial Carcinoma	GDSC	PPATPLAS	DEG_SCF_FBW7_1	0.1667
p.R87M	ACH-000940	Endometrial/Uterine Cancer	CCLE	PPATPLAS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y662	Heparan sulfate glucosamine 3-O-sulfotransferase 3B1	DEG_SCF_FBW7_1	93:100	PPATPLAS	FBXW7	0.8886	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons