DegronMD

Uniprot ID: Q9NVV2

Source protein: Putative uncharacterized protein C19orf73

Source gene: C19orf73

Class: DEG_SCF_FBW7_1

Location: 48:55

E3 ligase: FBXW7

DEGRON score: 0.8788

ASA_SCORE: 75.8875

COIL: 0.8439

CONS_SCORE: 0.9392

DSS_SCORE: 0.7049

HELIX: 0.0291

FCONS_SCORE: 0.9434

RIG_SCORE: 0.6026

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V57L	TCGA-60-2711	LUSC	TCGA	PPATPTQT	DEG_SCF_FBW7_1	0.2778
p.V57L	TCGA-BH-A5IZ	BRCA	TCGA	PPATPTQT	DEG_SCF_FBW7_1	0.2778
p.V57L	DO219607	BRCA	ICGC	PPATPTQT	DEG_SCF_FBW7_1	0.2778
p.V57L	DO26987	LUSC	ICGC	PPATPTQT	DEG_SCF_FBW7_1	0.2778
p.R64W	TCGA-77-A5GB	LUSC	TCGA	PPATPTQT	DEG_SCF_FBW7_1	0.0833
p.R64W	DO45439	LUSC	ICGC	PPATPTQT	DEG_SCF_FBW7_1	0.0833
p.R64L	TCGA-D3-A3C7	SKCM	TCGA	PPATPTQT	DEG_SCF_FBW7_1	0.0833
p.R64L	DO47569	SKCM	ICGC	PPATPTQT	DEG_SCF_FBW7_1	0.0833
p.A60E	DO228976	LICA	ICGC	PPATPTQT	DEG_SCF_FBW7_1	0.1944
p.A46E	DO229041	LICA	ICGC	PPATPTQT	DEG_SCF_FBW7_1	0.2778
p.A46T	DO232761	PBCA	ICGC	PPATPTQT	DEG_SCF_FBW7_1	0.2778
p.P48R	SIDM00582	Pancreatic Carcinoma	GDSC	PPATPTQT	DEG_SCF_FBW7_1	0.7512
p.P48R	SIDM00425	Ovarian Carcinoma	GDSC	PPATPTQT	DEG_SCF_FBW7_1	0.7512
p.P48R	ACH-000281	Pancreatic Cancer	CCLE	PPATPTQT	DEG_SCF_FBW7_1	0.7512
p.P48R	ACH-000663	Ovarian Cancer	CCLE	PPATPTQT	DEG_SCF_FBW7_1	0.7512

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NVV2	Putative uncharacterized protein C19orf73	DEG_SCF_FBW7_1	48:55	PPATPTQT	FBXW7	0.8788	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons