DegronMD

Uniprot ID: Q2M296

Source protein: Methenyltetrahydrofolate synthase domain-containing protein

Source gene: MTHFSD

Class: DEG_SCF_FBW7_2

Location: 279:286

E3 ligase: FBXW7

DEGRON score: 0.9403

ASA_SCORE: 88.2625

COIL: 0.941

CONS_SCORE: 0.467

DSS_SCORE: 0.8193

HELIX: 0.0413

FCONS_SCORE: 1.0549

RIG_SCORE: 0.5345

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G295C	TCGA-AA-3864	COAD	TCGA	PPDTPGPE	DEG_SCF_FBW7_2	0.0833
p.S295C	DO228483	BRCA	ICGC	PPDTPGPE	DEG_SCF_FBW7_2	0.0833
p.S295C	DO229013	COCA	ICGC	PPDTPGPE	DEG_SCF_FBW7_2	0.0833
p.S295C	DO229016	COCA	ICGC	PPDTPGPE	DEG_SCF_FBW7_2	0.0833
p.S295C	DO229003	COCA	ICGC	PPDTPGPE	DEG_SCF_FBW7_2	0.0833
p.S295C	DO229005	COCA	ICGC	PPDTPGPE	DEG_SCF_FBW7_2	0.0833
p.S295C	DO229346	LAML	ICGC	PPDTPGPE	DEG_SCF_FBW7_2	0.0833
p.S295C	DO229505	LAML	ICGC	PPDTPGPE	DEG_SCF_FBW7_2	0.0833
p.S295C	DO229047	LICA	ICGC	PPDTPGPE	DEG_SCF_FBW7_2	0.0833
p.G294C	DO8490	COAD	ICGC	PPDTPGPE	DEG_SCF_FBW7_2	0.1111
p.P284Q	DO228971	LICA	ICGC	PPDTPGPE	DEG_SCF_FBW7_2	0.7035
p.T282K	SIDM01293	Colorectal Carcinoma	GDSC	PPDTPGPE	DEG_SCF_FBW7_2	0.7306
p.P283T	SIDM01652	Non-Cancerous	GDSC	PPDTPGPE	DEG_SCF_FBW7_2	0.7031
p.P283T	ACH-002352	Non-Cancerous	CCLE	PPDTPGPE	DEG_SCF_FBW7_2	0.7031
p.P280L	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PPDTPGPE	DEG_SCF_FBW7_2	0.6471
p.P280L	ACH-000878	Lung Cancer	CCLE	PPDTPGPE	DEG_SCF_FBW7_2	0.6471
p.P280L	HCC-15	lung	COSMIC	PPDTPGPE	DEG_SCF_FBW7_2	0.6471
p.Q269E	SIDM01409	Bladder Carcinoma	GDSC	PPDTPGPE	DEG_SCF_FBW7_2	0.0556
p.Q269E	SIDM01387	Small Cell Lung Carcinoma	GDSC	PPDTPGPE	DEG_SCF_FBW7_2	0.0556
p.N288D	ACH-000978	Endometrial/Uterine Cancer	CCLE	PPDTPGPE	DEG_SCF_FBW7_2	0.2778
p.P279L	HCC-15	lung	COSMIC	PPDTPGPE	DEG_SCF_FBW7_2	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2M296	Methenyltetrahydrofolate synthase domain-containing protein	DEG_SCF_FBW7_2	279:286	PPDTPGPE	FBXW7	0.9403	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons