DegronMD

Uniprot ID: Q13127

Source protein: RE1-silencing transcription factor

Source gene: REST

Class: DEG_SCF_FBW7_2

Location: 141:148

E3 ligase: FBXW7

DEGRON score: 0.6379

ASA_SCORE: 86.35

COIL: 0.8198

CONS_SCORE: 0.5088

DSS_SCORE: 0.7009

HELIX: 0.1309

FCONS_SCORE: 1.0595

RIG_SCORE: 0.589

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K155N	TCGA-06-5416	GBM	TCGA	PPETPGAE	DEG_SCF_FBW7_2	0.25
p.K155N	DO10880	GBM	ICGC	PPETPGAE	DEG_SCF_FBW7_2	0.25
p.A147T	TCGA-A5-A0G1	UCEC	TCGA	PPETPGAE	DEG_SCF_FBW7_2	0.6028
p.A147T	DO42472	UCEC	ICGC	PPETPGAE	DEG_SCF_FBW7_2	0.6028
p.D139N	TCGA-A5-A0G2	UCEC	TCGA	PPETPGAE	DEG_SCF_FBW7_2	0.2778
p.D139N	DO41235	UCEC	ICGC	PPETPGAE	DEG_SCF_FBW7_2	0.2778
p.D149G	TCGA-CG-5721	STAD	TCGA	PPETPGAE	DEG_SCF_FBW7_2	0.3056
p.D149G	DO38192	STAD	ICGC	PPETPGAE	DEG_SCF_FBW7_2	0.3056
p.P141S	TCGA-EE-A2MJ	SKCM	TCGA	PPETPGAE	DEG_SCF_FBW7_2	0.6752
p.P141S	DO38099	SKCM	ICGC	PPETPGAE	DEG_SCF_FBW7_2	0.6752
p.K152T	TCGA-EO-A3AY	UCEC	TCGA	PPETPGAE	DEG_SCF_FBW7_2	0.3333
p.K152T	DO43202	UCEC	ICGC	PPETPGAE	DEG_SCF_FBW7_2	0.3333
p.G151D	DO229018	LICA	ICGC	PPETPGAE	DEG_SCF_FBW7_2	0.25
p.P141R	SIDM00944	Colorectal Carcinoma	GDSC	PPETPGAE	DEG_SCF_FBW7_2	0.7512
p.P141R	CL-11	large_intestine	COSMIC	PPETPGAE	DEG_SCF_FBW7_2	0.7512
p.D132H	SIDM00420	Bladder Carcinoma	GDSC	PPETPGAE	DEG_SCF_FBW7_2	0.0833
p.D132H	ACH-000566	Bladder Cancer	CCLE	PPETPGAE	DEG_SCF_FBW7_2	0.0833
p.D132H	SW1710	urinary_tract	COSMIC	PPETPGAE	DEG_SCF_FBW7_2	0.0833
p.S154L	ACH-000999	Colon/Colorectal Cancer	CCLE	PPETPGAE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13127	RE1-silencing transcription factor	DEG_SCF_FBW7_2	141:148	PPETPGAE	FBXW7	0.6379	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons