DegronMD

Uniprot ID: Q9NZJ0

Source protein: Denticleless protein homolog

Source gene: DTL

Class: DEG_SCF_FBW7_1

Location: 513:520

E3 ligase: FBXW7

DEGRON score: 0.9924

ASA_SCORE: 72.225

COIL: 0.8934

CONS_SCORE: 0.4071

DSS_SCORE: 0.6572

HELIX: 0.0358

FCONS_SCORE: 1.0416

RIG_SCORE: 0.6113

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S520L	TCGA-D1-A0ZO	UCEC	TCGA	PPITPPAS	DEG_SCF_FBW7_1	0.8778
p.S520L	TCGA-KQ-A41R	BLCA	TCGA	PPITPPAS	DEG_SCF_FBW7_1	0.8778
p.P517L	TCGA-D3-A5GS	SKCM	TCGA	PPITPPAS	DEG_SCF_FBW7_1	0.7582
p.V521L	DO229037	LICA	ICGC	PPITPPAS	DEG_SCF_FBW7_1	0.3056
p.K522Q	Hep_3B2_1-7	NS	COSMIC	PPITPPAS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZJ0	Denticleless protein homolog	DEG_SCF_FBW7_1	513:520	PPITPPAS	FBXW7	0.9924	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons