DegronMD

Uniprot ID: Q9NR09

Source protein: Baculoviral IAP repeat-containing protein 6

Source gene: BIRC6

Class: DEG_SCF_FBW7_2

Location: 1707:1714

E3 ligase: FBXW7

DEGRON score: 0.8837

ASA_SCORE: 82.85

COIL: 0.9095

CONS_SCORE: 0.518

DSS_SCORE: 0.3357

HELIX: 0.0569

FCONS_SCORE: 1.1219

RIG_SCORE: 0.7206

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1719A	TCGA-AA-3864	COAD	TCGA	PPLTPPNE	DEG_SCF_FBW7_2	0.1944
p.V1719A	DO8490	COAD	ICGC	PPLTPPNE	DEG_SCF_FBW7_2	0.1944
p.V1716I	TCGA-AA-3984	COAD	TCGA	PPLTPPNE	DEG_SCF_FBW7_2	0.2778
p.V1716I	DO9002	COAD	ICGC	PPLTPPNE	DEG_SCF_FBW7_2	0.2778
p.E1723K	TCGA-AZ-4315	COAD	TCGA	PPLTPPNE	DEG_SCF_FBW7_2	0.0833
p.E1723K	TCGA-D1-A16Y	UCEC	TCGA	PPLTPPNE	DEG_SCF_FBW7_2	0.0833
p.E1723K	DO8842	COAD	ICGC	PPLTPPNE	DEG_SCF_FBW7_2	0.0833
p.E1723K	DO41524	UCEC	ICGC	PPLTPPNE	DEG_SCF_FBW7_2	0.0833
p.A1715S	TCGA-BP-5169	KIRC	TCGA	PPLTPPNE	DEG_SCF_FBW7_2	0.3056
p.A1715S	DO18075	KIRC	ICGC	PPLTPPNE	DEG_SCF_FBW7_2	0.3056
p.T1710S	TCGA-XR-A8TG	LIHC	TCGA	PPLTPPNE	DEG_SCF_FBW7_2	0.8227
p.T1710S	DO223924	LIHC	ICGC	PPLTPPNE	DEG_SCF_FBW7_2	0.8227

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR09	Baculoviral IAP repeat-containing protein 6	DEG_SCF_FBW7_2	1707:1714	PPLTPPNE	FBXW7	0.8837	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons