DegronMD

Uniprot ID: Q9NQC3

Source protein: Reticulon-4

Source gene: RTN4

Class: DEG_SIAH_1

Location: 146:154

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.993

ASA_SCORE: 95.8667

COIL: 0.9614

CONS_SCORE: 0.6174

DSS_SCORE: 0.7408

HELIX: 0.0187

FCONS_SCORE: 0.9963

RIG_SCORE: 0.477

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M148V	DO8264	COAD	ICGC	PPPASVSPQ	DEG_SIAH_1	0.7208
p.P147A	DO25867	LUAD	ICGC	PPPASVSPQ	DEG_SIAH_1	0.7503
p.D161V	DO51407	PRAD	ICGC	PPPASVSPQ	DEG_SIAH_1	0.1389
p.S150R	DO229211	THCA	ICGC	PPPASVSPQ	DEG_SIAH_1	0.6316
p.P146S	ACH-000987	Skin Cancer	CCLE	PPPASVSPQ	DEG_SIAH_1	0.5641
p.V151A	ACH-000990	Endometrial/Uterine Cancer	CCLE	PPPASVSPQ	DEG_SIAH_1	0.6936
p.P146H	ACH-000998	Colon/Colorectal Cancer	CCLE	PPPASVSPQ	DEG_SIAH_1	0.6583

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQC3	Reticulon-4	DEG_SIAH_1	146:154	PPPASVSPQ	SIAH1,SIAH2,SIAH3	0.993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons