DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PPPTPAPS
Uniprot ID:
O95685
Source protein:
Protein phosphatase 1 regulatory subunit 3D
Source gene:
PPP1R3D
Class:
DEG_SCF_FBW7_1
Location:
51:58
E3 ligase:
FBXW7
DEGRON score:
0.7736
ASA_SCORE:
91.275
COIL:
0.9655
CONS_SCORE:
0.3238
DSS_SCORE:
0.7679
HELIX:
0.017
FCONS_SCORE:
0.8688
RIG_SCORE:
0.5224
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D61A
DO219881
SKCA
ICGC
PPPTPAPS
DEG_SCF_FBW7_1
0.25
p.S58W
SIDM00867
Glioblastoma
GDSC
PPPTPAPS
DEG_SCF_FBW7_1
0.7874
Drug responses associated with PPP1R3D mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPPTPAPS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95685
Protein phosphatase 1 regulatory subunit 3D
DEG_SCF_FBW7_1
51:58
PPPTPAPS
FBXW7
0.7736
More...