DegronMD

Uniprot ID: P46379

Source protein: Large proline-rich protein BAG6

Source gene: BAG6

Class: DEG_SCF_FBW7_2

Location: 394:401

E3 ligase: FBXW7

DEGRON score: 0.9931

ASA_SCORE: 100.8

COIL: 0.9661

CONS_SCORE: 0.4091

DSS_SCORE: 0.8346

HELIX: 0.0188

FCONS_SCORE: 1.1234

RIG_SCORE: 0.5696

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P398S	TCGA-LH-A9QB	SKCM	TCGA	PPPTPNAE	DEG_SCF_FBW7_2	0.6752
p.S406C	DO26354	LUAD	ICGC	PPPTPNAE	DEG_SCF_FBW7_2	0.1944
p.P392S	DO220851	MELA	ICGC	PPPTPNAE	DEG_SCF_FBW7_2	0.2778
p.P392S	DO51266	SKCM	ICGC	PPPTPNAE	DEG_SCF_FBW7_2	0.2778
p.P398T	DO220872	MELA	ICGC	PPPTPNAE	DEG_SCF_FBW7_2	0.7031
p.P401L	DO220884	MELA	ICGC	PPPTPNAE	DEG_SCF_FBW7_2	0.7582
p.P389S	DO222550	MELA	ICGC	PPPTPNAE	DEG_SCF_FBW7_2	0.1944
p.A396V	DO229103	THCA	ICGC	PPPTPNAE	DEG_SCF_FBW7_2	0.6936
p.P398L	SIDM01060	Melanoma	GDSC	PPPTPNAE	DEG_SCF_FBW7_2	0.7582
p.P398L	IGR-1	skin	COSMIC	PPPTPNAE	DEG_SCF_FBW7_2	0.7582
p.T386I	SIDM00596	Endometrial Carcinoma	GDSC	PPPTPNAE	DEG_SCF_FBW7_2	0.1111
p.T386I	HEC-1	endometrium	COSMIC	PPPTPNAE	DEG_SCF_FBW7_2	0.1111
p.A402S	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	PPPTPNAE	DEG_SCF_FBW7_2	0.3056
p.A402S	KNS-62	lung	COSMIC	PPPTPNAE	DEG_SCF_FBW7_2	0.3056
p.P394H	SIDM01682	Gastric Carcinoma	GDSC	PPPTPNAE	DEG_SCF_FBW7_2	0.7694
p.P388H	ACH-000110	Gastric Cancer	CCLE	PPPTPNAE	DEG_SCF_FBW7_2	0.1667
p.A396S	ACH-000858	Lung Cancer	CCLE	PPPTPNAE	DEG_SCF_FBW7_2	0.7588
p.A396S	KNS-62	lung	COSMIC	PPPTPNAE	DEG_SCF_FBW7_2	0.7588
p.P392L	ACH-000882	Skin Cancer	CCLE	PPPTPNAE	DEG_SCF_FBW7_2	0.2778
p.P392L	IGR-1	skin	COSMIC	PPPTPNAE	DEG_SCF_FBW7_2	0.2778
p.P399R	ACH-001622	Brain Cancer	CCLE	PPPTPNAE	DEG_SCF_FBW7_2	0.7512

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46379	Large proline-rich protein BAG6	DEG_SCF_FBW7_2	394:401	PPPTPNAE	FBXW7	0.9931	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons