DegronMD

Uniprot ID: P23246

Source protein: Splicing factor, proline- and glutamine-rich

Source gene: SFPQ

Class: DEG_SCF_FBW7_1

Location: 165:172

E3 ligase: FBXW7

DEGRON score: 0.9288

ASA_SCORE: 106.0625

COIL: 0.9791

CONS_SCORE: 0.313

DSS_SCORE: 0.7774

HELIX: 0.0095

FCONS_SCORE: 0.9193

RIG_SCORE: 0.425

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V157I	DO227979	COCA	ICGC	PPPTPPSS	DEG_SCF_FBW7_1	0.1111
p.A160T	DO228349	MALY	ICGC	PPPTPPSS	DEG_SCF_FBW7_1	0.1944
p.A160T	ACH-000944	Lymphoma	CCLE	PPPTPPSS	DEG_SCF_FBW7_1	0.1944
p.P161S	DO229250	THCA	ICGC	PPPTPPSS	DEG_SCF_FBW7_1	0.2222
p.G163R	SIDM00706	Small Cell Lung Carcinoma	GDSC	PPPTPPSS	DEG_SCF_FBW7_1	0.2778
p.G163R	ACH-000290	Lung Cancer	CCLE	PPPTPPSS	DEG_SCF_FBW7_1	0.2778
p.P179L	ACH-000659	Lung Cancer	CCLE	PPPTPPSS	DEG_SCF_FBW7_1	0.1389
p.P155L	ACH-000971	Colon/Colorectal Cancer	CCLE	PPPTPPSS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23246	Splicing factor, proline- and glutamine-rich	DEG_SCF_FBW7_1	165:172	PPPTPPSS	FBXW7	0.9288	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons