DegronMD

Uniprot ID: P46379

Source protein: Large proline-rich protein BAG6

Source gene: BAG6

Class: DEG_SCF_FBW7_1

Location: 594:601

E3 ligase: FBXW7

DEGRON score: 0.9881

ASA_SCORE: 93.6

COIL: 0.9475

CONS_SCORE: 0.4067

DSS_SCORE: 0.8325

HELIX: 0.0335

FCONS_SCORE: 1.1134

RIG_SCORE: 0.5962

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S601C	TCGA-A2-A04Q	BRCA	TCGA	PPPTPQPS	DEG_SCF_FBW7_1	0.7541
p.A603T	TCGA-AP-A1DV	UCEC	TCGA	PPPTPQPS	DEG_SCF_FBW7_1	0.2778
p.S595C	DO1678	BRCA	ICGC	PPPTPQPS	DEG_SCF_FBW7_1	0.7541
p.F601L	DO45109	LIRI	ICGC	PPPTPQPS	DEG_SCF_FBW7_1	0.6981
p.A597T	DO43186	UCEC	ICGC	PPPTPQPS	DEG_SCF_FBW7_1	0.7139
p.M602T	SIDM01101	Neuroblastoma	GDSC	PPPTPQPS	DEG_SCF_FBW7_1	0.3056
p.M602T	ACH-000260	Neuroblastoma	CCLE	PPPTPQPS	DEG_SCF_FBW7_1	0.3056
p.M602T	SK-N-AS	autonomic_ganglia	COSMIC	PPPTPQPS	DEG_SCF_FBW7_1	0.3056
p.M596T	SK-N-AS	autonomic_ganglia	COSMIC	PPPTPQPS	DEG_SCF_FBW7_1	0.7423
p.E592K	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PPPTPQPS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46379	Large proline-rich protein BAG6	DEG_SCF_FBW7_1	594:601	PPPTPQPS	FBXW7	0.9881	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons