DegronMD

Uniprot ID: Q9BQY9

Source protein: Dysbindin domain-containing protein 2

Source gene: DBNDD2

Class: DEG_SCF_FBW7_1

Location: 183:190

E3 ligase: FBXW7

DEGRON score: 0.9678

ASA_SCORE: 79.75

COIL: 0.9309

CONS_SCORE: 0.7283

DSS_SCORE: 0.7698

HELIX: 0.0354

FCONS_SCORE: 0.8385

RIG_SCORE: 0.567

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S194F	TCGA-20-0991	OV	TCGA	PPPTPQSS	DEG_SCF_FBW7_1	0.2222
p.S193L	TCGA-W3-A828	SKCM	TCGA	PPPTPQSS	DEG_SCF_FBW7_1	0.25
p.P187R	SIDM00625	Other Sarcomas	GDSC	PPPTPQSS	DEG_SCF_FBW7_1	0.7512
p.P187R	MES-SA	soft_tissue	COSMIC	PPPTPQSS	DEG_SCF_FBW7_1	0.7512
p.P175L	SIDM01753	Gastric Carcinoma	GDSC	PPPTPQSS	DEG_SCF_FBW7_1	0.1111
p.P183R	MES-SA	soft_tissue	COSMIC	PPPTPQSS	DEG_SCF_FBW7_1	0.7512

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQY9	Dysbindin domain-containing protein 2	DEG_SCF_FBW7_1	183:190	PPPTPQSS	FBXW7	0.9678	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons