DegronMD

Uniprot ID: Q6NT89

Source protein: TMF-regulated nuclear protein 1

Source gene: TRNP1

Class: DEG_SCF_FBW7_1

Location: 36:43

E3 ligase: FBXW7

DEGRON score: 0.8533

ASA_SCORE: 94.85

COIL: 0.9765

CONS_SCORE: 0.58

DSS_SCORE: 0.91

HELIX: 0.0101

FCONS_SCORE: 0.9004

RIG_SCORE: 0.4836

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W27R	DO229010	COCA	ICGC	PPPTPTLT	DEG_SCF_FBW7_1	0.0833
p.W27R	DO229013	COCA	ICGC	PPPTPTLT	DEG_SCF_FBW7_1	0.0833
p.W27R	DO229016	COCA	ICGC	PPPTPTLT	DEG_SCF_FBW7_1	0.0833
p.W27R	DO229003	COCA	ICGC	PPPTPTLT	DEG_SCF_FBW7_1	0.0833
p.W27R	DO229005	COCA	ICGC	PPPTPTLT	DEG_SCF_FBW7_1	0.0833
p.P31S	ACH-000982	Colon/Colorectal Cancer	CCLE	PPPTPTLT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NT89	TMF-regulated nuclear protein 1	DEG_SCF_FBW7_1	36:43	PPPTPTLT	FBXW7	0.8533	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons