DegronMD

Uniprot ID: Q9Y572

Source protein: Receptor-interacting serine/threonine-protein kinase 3

Source gene: RIPK3

Class: DEG_SCF_FBW7_1

Location: 395:402

E3 ligase: FBXW7

DEGRON score: 0.9912

ASA_SCORE: 90.725

COIL: 0.9395

CONS_SCORE: 0.3328

DSS_SCORE: 0.8587

HELIX: 0.0289

FCONS_SCORE: 1.0804

RIG_SCORE: 0.5872

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S391L	TCGA-AA-A00N	COAD	TCGA	PPQTPETS	DEG_SCF_FBW7_1	0.2222
p.S391L	DO9876	COAD	ICGC	PPQTPETS	DEG_SCF_FBW7_1	0.2222
p.S391L	SIDM01276	Colorectal Carcinoma	GDSC	PPQTPETS	DEG_SCF_FBW7_1	0.2222
p.P409S	TCGA-CK-4951	COAD	TCGA	PPQTPETS	DEG_SCF_FBW7_1	0.1389
p.P409S	DO10582	COAD	ICGC	PPQTPETS	DEG_SCF_FBW7_1	0.1389
p.P409H	TCGA-D3-A2J6	SKCM	TCGA	PPQTPETS	DEG_SCF_FBW7_1	0.1389
p.P409H	DO37901	SKCM	ICGC	PPQTPETS	DEG_SCF_FBW7_1	0.1389
p.P411S	TCGA-EE-A29L	SKCM	TCGA	PPQTPETS	DEG_SCF_FBW7_1	0.0833
p.P411S	DO222599	MELA	ICGC	PPQTPETS	DEG_SCF_FBW7_1	0.0833
p.P411S	DO37835	SKCM	ICGC	PPQTPETS	DEG_SCF_FBW7_1	0.0833
p.D390Y	TCGA-FI-A2D0	UCEC	TCGA	PPQTPETS	DEG_SCF_FBW7_1	0.1944
p.D390Y	DO43891	UCEC	ICGC	PPQTPETS	DEG_SCF_FBW7_1	0.1944
p.A393D	DO228952	LICA	ICGC	PPQTPETS	DEG_SCF_FBW7_1	0.2778
p.S410R	DO229036	LICA	ICGC	PPQTPETS	DEG_SCF_FBW7_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y572	Receptor-interacting serine/threonine-protein kinase 3	DEG_SCF_FBW7_1	395:402	PPQTPETS	FBXW7	0.9912	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons