DegronMD

Uniprot ID: Q9Y6V7

Source protein: Probable ATP-dependent RNA helicase DDX49

Source gene: DDX49

Class: DEG_SCF_FBW7_1

Location: 465:472

E3 ligase: FBXW7

DEGRON score: 0.9879

ASA_SCORE: 105.5375

COIL: 0.9721

CONS_SCORE: 0.2316

DSS_SCORE: 0.907

HELIX: 0.0151

FCONS_SCORE: 1.0022

RIG_SCORE: 0.4765

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S472P	DO230323	COCA	ICGC	PPRTPSGS	DEG_SCF_FBW7_1	0.6752
p.A459D	DO229208	THCA	ICGC	PPRTPSGS	DEG_SCF_FBW7_1	0.1667
p.R464H	SIDM00252	Biliary Tract Carcinoma	GDSC	PPRTPSGS	DEG_SCF_FBW7_1	0.3056
p.R467G	SIDM01590	Breast Carcinoma	GDSC	PPRTPSGS	DEG_SCF_FBW7_1	0.6457
p.A459V	ACH-000995	Leukemia	CCLE	PPRTPSGS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6V7	Probable ATP-dependent RNA helicase DDX49	DEG_SCF_FBW7_1	465:472	PPRTPSGS	FBXW7	0.9879	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons